Yeda Research and Develpment & Co. Ltd

Avner Fink

Yechiel Shai

Zelig Eshhar

Tova Waks

Liraz Shmuel-Galia

Shay Yaari

Eliran-Moshe Reuven

Christopher J Arnush

Christopher J Arnusch

Peptides are provided that are capable of inhibiting cell activation mediated by a Toll-like receptor (TLR) selected from TLR 1, 2, 4 or 6, said peptide comprising a sequence consisting of, or found within, the sequence of the transmembrane domain of a TLR selected from TLR 1, 2, 4 or 6 and optionally cytoplasmic and extracellular regions flanking the transmembrane domain. These peptides as well as pharmaceutical composition comprising them are useful for the treatment of TLR-mediated disease.

Peptides based on the transmembrane domain of a toll-like receptor (TLR) for treatment of TLR-mediated diseases

Isolated peptides of 13-30 amino acids comprising 5-9 consecutive repeats of the amino acid pair Alanine-Leucine or Alanine-Valine are provided. The peptides further comprise a stretch of 1-3 Lysine residues present at least at one of the peptide's termini, wherein the only Lysine residue in the isolated peptide is present at the stretch of 1-3 Lysine residues. Pharmaceutical compositions comprising same, methods of treating inflammatory conditions and allergic reactions, as well as methods of neutralizing the activity of lypopolysaccharides are also provided.

Anti-inflammatory peptides and use thereof

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Rehovot, Israel

Avner Fink