California Institute of Technology

The State University of New York

The Scripps Research Institute

Avinash Muppidi

Peter G Schultz

Weijun Shen

Pengyu Yang

Qing Lin

Insha Ahmad

Huafei Zou

Yulin Tian

Andreas Crameri

Methods and compositions are provided for extending the half-life of a therapeutic agent. One or more half-life extending moieties may be attached to a therapeutic agent, thereby extending the half life of the therapeutic agent. The modified therapeutic agents (mTAs) comprising one or more half-life extending moieties attached to a therapeutic agent may be used to treat a disease or condition in a subject in need thereof.

Modified therapeutic agents and compositions thereof

Provided are oxyntomodulin analogs. The peptide analogs have at least two cysteines. The two cysteines are separated by six amino acids such that they can be crosslinked using suitable crosslinking moieties. The crosslinked peptides have long half-lives and/or efficacy. For example, peptide analog compositions are used for inducing weight loss and/or reducing blood glucose levels.

Oxyntomodulin analogs and methods of making and using same

Cross-linked proteins and peptides, and methods of making and uses of such cross-linked proteins and peptides. The cross-linked proteins and peptides have rigid, distance-matching bismethylene aryl cross-linking moieties. Compositions comprising the cross-linked proteins and peptides can be used as pharmaceutical delivery formulations. The cross-linked proteins and peptides can have improved properties, such as cell permeability, as compared to the parent protein or peptide.

Cross-linked peptides and proteins, methods of making same, and uses thereof

Growing community of inventors

La Jolla, CA, United States of America

Avinash Muppidi