Washington University

Avik Som

Samuel I Achilefu

Pratim Biswas

Kexian Liang

Rui Tang

Partha Karmakar

Gail Sudlow

Baogang Xu

Duanwen Shen

Ramesh Raliya

Christopher Egbulefu

Provided herein is a pharmaceutical composition comprising an effective amount of cypate-Cyclo(Cys-Gly-Arg-Asp-Ser-Pro-Cys)-Lys-OH (LS301), cypate-Cyclo(Cys-Gly-Arg-Asp-Ser-Pro-Cys)-Tyr-OH (LS838) or pharmaceutically acceptable salts thereof, wherein each amino acid residue is independently in a D or L configuration; a divalent metal ion; and a pharmaceutically acceptable carrier. Further provided are lyophilized products comprising a dye-conjugate and m methods for identifying compromised and for binding phosphorylated annexin A2 (pANXA2) protein in a biological sample using a composition described herein.

Near infrared fluorescent dyes, formulations and related methods

Disclosed are compositions comprising calcium carbonate nanoparticles and albumin. Also disclosed are compositions wherein the calcium carbonate nanoparticles further comprise targeting ligands, coatings, therapeutic agents and dyes. The compositions can be used in methods for neutralizing extracellular pH and in treating cancer.

Nano-calcium carbonate

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Houston, TX, United States of America

Avik Som