Adama Agan Ltd.

Pharmos Corporation

Clevexel Pharma

Dynamix Pharmaceuticals Ltd.

Avihai Yacovan

Oren Becker

Gali Golan

Sima Mirilashvili

Vered Behar

Nili Schutz

Omer Tzor

Alina Shitrit

Efrat Ben-Zeev

Nataliya Kalinovich

Yaniv Barda

Iris Alroy

Gerd-Volker Roeschenthaler

Alex Aizikovich

Shmuel A Baron

Alexander Aizikovich

Olesya Stubbmann-Kazakova

Mykhailo Shevchuk

Sveta Fronton

Leonid Erchov

Alexander Shterenberg

Itai Bloch

Osnat Kashtan

Daniel Sherman

Tzofit Kehat

Rachel Ozeri

Alexander Konson

Sharon Gazal

Flavio Grynszpan

Tzurit Kusneic

Oren M Becker

The present subject matter provides a safe alternative for producing an important intermediate useful for preparing the herbicide glufosinate, without need for chlorine components in the manufacturing process. In particular, a process for preparing alkyl phosphinic aid alkyl ester is provided, including the step of alkylating alkyl phosphinic acid ester in a non-polar solvent in the same apparatus as used to first produce the alkyl phosphinic acid ester, and without isolating the alkyl phosphinic acid ester before the alkylation step is conducted. More specifically, a process is presented for preparing methyl phosphinic acid butyl ester, by alkylating butyl phosphinic acid ester in a non-polar solvent, in the same apparatus as used previously to first produce the butyl phosphinic acid ester and without isolating the butylphosphinic acid ester before alkylation.

Process for preparing methyl phosphinic acid butyl ester

It is an object of the present invention to provide a novel and advantageous process for commercially preparing quinmerac.

Process for the preparation of Quinmerac

The present invention provides a process for preparing a compound of the formula (I): 

Process for preparing methoxy methyl pyridine dicarboxylate

A process for preparing, 1,1,3-Trioxo-1,2-benzothiazole-6-carboxamide of formula (I) comprising: reacting 2-chloro-sulfonyl-terephthalic acid dialkyl ester of formula (II) with ammonia (N H) or ammonium containing-salt; wherein R represents a branched or non-branched C-Calkyl.

Process for preparing 1,1,3-trioxo-1,2-benzothiazole-6-carboxamide

The invention provides sulfonamide compounds of formula (I) as defined herein, pharmaceutical compositions containing the same and methods of treatment using such compounds and pharmaceutical compositions. These compounds have a common wide range of beneficial therapeutic indications, in particular as analgesic and anti-inflammatory agents.

Sulfonamide derivatives with therapeutic indications

The invention relates to compounds and methods for modulating one or more components of a kinase signaling cascade.

Compositions and methods for modulating a kinase

The invention relates to sulfonamide compounds and methods for activating PKM2. The compounds and methods are useful in treating or preventing a disease or disorder selected from cancer, cell proliferative disorder, inflammatory disorder, metabolic disorder, and immune system disorder.

Sulfonamides for the modulation of PKM2

Growing community of inventors

Gedera, Israel

Avihai Yacovan