The Broad Institute, Inc.

International Business Machines Corporation

Dana-farber-cancer Institute Inc.

Instituto Carlos Slim De La Salud, A.c.

Aviad Tsherniak

Sivan Sabato

Elad Yom-Tov

William C Hahn

David Root

Andrew J Aguirre

Robin M Meyers

Jesse Boehm

Barbara Weir

Mushriq Muhib Al-Jazrawe

Francisca Vazquez

Jt Neal

Mahmoud Ghandi

Glenn Cowley

Niklas Rindtorff

James McFarland

Adam Bass

Tsukasa Shibue

April Cook

Edmond Chan

The present disclosure relates to compositions and methods for the diagnosis and treatment or prevention of microsatellite unstable cancers. In particular, the instant disclosure provides for identification of a cancer as exhibiting microsatellite instability (MSI) and/or impaired mismatch repair (MMR), and selection and/or administration of an inhibitor of the WRN helicase as a therapeutic agent for such a cancer and/or subject having or at risk of developing such a cancer.

Therapeutic treatment of microsatellite unstable cancers

Ex vivo cell-based living biosensors, methods of imaging and identifying cell types and/or cell phenotypes, and uses of the systems and methods are provided.

Living biosensors

The present invention relates to compositions and methods for targeting cancer-specific DNA sequences, such as copy number amplifications and other types of cancer-specific sequence variations, such as cancer-specific polymorphisms, insertions, or deletions. The present invention provides hereto sequence-specific DNA targeting agents targeting a sequence within the amplified DNA region or a sequence otherwise specific for a cancer cell compared to a non-cancer cell. The invention further relates to methods for treating cancer, comprising administering such sequence-specific DNA targeting agents. The invention further relates to methods for preparing sequence-specific DNA targeting agent, as well as screening methods using the DNA targeting agents.

Compositions and methods for targeting cancer-specific sequence variations

A novel and useful method for enabling system logs to be effectively and efficiently monitored by ranking the system log messages by their estimated value to administrators and generating a log view that displays the most important messages. The ranking process uses a dataset of system logs from many computer systems to score messages. For better scoring, unsupervised clustering is used to identify sets of systems that behave similarly. The expected distribution of messages in a given system is estimated using the resulting clusters, and log messages are scored using this estimation.

Apparatus for and method of implementing system log message ranking via system behavior analysis

A method for visual representation of time based events in a target system comprises analyzing content related to occurrence of one or more events in a target system, wherein the content comprises information from which type of an event and time of occurrence of the event may be determined; grouping the events into one or more classes according to one or more predefined attributes; and generating a visual presentation of events occurring in a first time range, wherein the time range is selectable by an independent entity.

System and method for visualization of time-based events

Growing community of inventors

Cambridge, MA, United States of America

Aviad Tsherniak