Beta-o2 Technologies Ltd.

Beta 02 Technologies Ltd.

Avi Rotem

Uriel Barkai

Tova Neufeld

Yehezkel Bremer

Pnina Vardi

Konstantin Bloch

Zohar Gendler

Yoav Evron

Yoram Rozy

Yaki Stern

Meir Reingewirtz

Chanan Schneider

Jacob Stern

Dimitry Azarov

Yoav Hevron

Baruch Zimerman

Yehezkel Bermer

A system is provided, including a plurality of donor cells and a first alginate structure that encapsulates the plurality of donor cells. The first alginate structure has a guluronic acid concentration of between 64% and 74%. The system additionally includes a second alginate structure that surrounds the first alginate structure, the second alginate structure having a mannuronic acid concentration of between 52% and 60%. A selectively-permeable membrane is coupled at least in part to the second alginate structure. Other embodiments are also described.

Multiple-layer immune barrier for donor cells

An implantable medical system that comprises a gas unit for supplying gas that is essentially oxygen and at least one functional cells unit configured to receive oxygen from the gas unit so as to maintain the cells in a viable condition. The cells unit is flexible. Several embodiments are disclosed.

Implantable medical devices

Apparatus is provided, including a plurality of islets, and a hydrogel configured to macroencapsulate the plurality of islets. The hydrogel is implantable in a subcapsular space () of a kidney () of a subject and is shaped to define a planar configuration. Other applications are also described.

Optimization of alginate encapsulation of islets for transplantation

A method for replenishing gas in a subcutaneously implanted medical device containing functional cells comprising: inserting at least one needle, adopted to penetrate the skin and connecting a subcutaneously implanted medical device; connecting the inserted at least one needle to a gas replenishing apparatus; extracting gas from a gas reservoir in the implanted device into the gas replenishing apparatus; sensing oxygen level in the extracted gas; calculating the amount of gas needed for replenishing oxygen in the reservoir based on the sensed oxygen level in the extracted gas; and supplying gas from a gas tank in the gas replenishing apparatus to the gas reservoir in the implanted device.

Oxygen supply for implantable medical device

Apparatus is provided, including a housing (), configured for insertion into a body of a patient; a photosynthetic oxygen supply () configured to supply oxygen; and functional cells (), coupled to the housing (). The functional cells () are adapted to receive the oxygen and to secrete at least one factor that induces vascularization in a vicinity of the housing () when the housing () is in the body of the patient. Other embodiments are also described.

Oxygen supply for cell transplant and vascularization

Apparatus is provided which includes a housing, configured for insertion into a body of a subject. The apparatus includes functional cells coupled to the housing and a source of oxygen configured to supply oxygen to the functional cells. The apparatus further includes an oxygen delivery interface configured to receive oxygen from the source of oxygen, and to facilitate passage of the oxygen to the functional cells, while the housing is disposed within the body of the subject. Other embodiments are also described.

Apparatus for transportation of oxygen to implanted cells

Apparatus is provided including a chamber, which is adapted to be implanted in a body of an individual, the chamber including functional cells and chlorophyll-containing elements comprising chlorophyll of an obligate photoautotroph.

Growing community of inventors

Petach Tikva, Israel

Avi Rotem