Robert Bosch

Isense Corporation

Autumn Maruniak

Sam Kavusi

Christopher Johnson

Nadezda Fomina

Habib Ahmad

Christoph Lang

Ashwin Raghunathan

Sung Hyun Lim

Young Shik Shin

Efthymios Papageorgiou

Armin Darvish

Nuria Queralto Gratacos

Device and methods for controlling pH or ionic gradient comprising a multisite array of feedback electrode sets comprising electrodes and pH sensing elements. The electrodes can include a reference electrode, counter electrode, and a working electrode. The device and methods iteratively select an amount of current and/or voltage to be applied to each working electrode, apply the selected amount of current and/or voltage to each working electrode to change pH of a solution close to the working electrode, and measure the signal output of the sensing element. The multisite array can include feedback and non-feedback electrode sets.

Electronic control of the pH of a solution close to an electrode surface

Device and methods for use in a biosensor comprising a multisite array of test sites, the device and methods being useful for modulating the binding interactions between a (biomolecular) probe or detection agent and an analyte of interest by modulating the pH or ionic gradient near the electrodes in such biosensor. An electrochemically active agent that is suitable for use in biological buffers for changing the pH of the biological buffers. Method for changing the pH of biological buffers using the electrochemically active agents. The methods of modulating the binding interactions provided in a biosensor, analytic methods for more accurately controlling and measuring the pH or ionic gradient near the electrodes in such biosensor, and analytic methods for more accurately measuring an analyte of interest in a biological sample.

Sensors arrays that include indicators arranged in a pattern on a substrate. The indicators include nucleophilic indicators. In some examples, the sensor arrays with multiple nucleophilic indicators provide superior detection and identification of microorganisms, cancer biomarkers, formaldehyde, organophosphates, and aldehydes.

Sensor arrays with nucleophilic indicators

Electrochemically active agents for pH modulation in biological buffers

Electronic control of the pH of a solution close to an electrode surfaces

A coated electrode includes an electrode, a coating configured to immobilize biomolecules, and a coating configured to improve electron transfer rate. Methods of making the coated electrode are also provided. A biosensor comprises a plurality of electrodes, each electrode including the coated electrode.

Electrode arrangement with improved electron transfer rates for redox of molecules

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Fremont, CA, United States of America

Autumn Maruniak