Ablynx N.v.

Wyeth

Zepteon, Incorporated

Austin Wayne Boesch

Paul Brown

Glen Bolton

Andrew M Wood

Scott Andreas Tobler

Hari Acharya

Glen Reed Bolton

Processes and methods of purifying or separating Single Domain Antigen Binding (SDAB) molecules that include one or more single binding domains (e.g., one or more nanobody molecules), substantially devoid of a complementary antibody domain and an immunoglobulin constant region, using Protein A-based affinity chromatography, are disclosed.

Methods for purification of single domain antigen binding molecules

The present disclosure provides methods and compositions for separating polypeptide glycoforms using a medium that includes an Fc receptor. In certain embodiments, a medium includes an Fc receptor which comprises an extracellular portion of an Fc gamma RIII receptor.

Polypeptide separation methods

The present invention relates to methods of generating highly concentrated protein solutions, e.g., an antibody solution, a therapeutic protein solution, etc. The methods of the invention include membrane evaporation, such as evaporation of protein-free solvent from the protein solution, which concentrates the protein. The methods of the present invention result in protein solution concentrations not previously achievable by conventional ultrafiltration methods, e.g., protein solution concentrations of greater than about 260 grams of protein per liter of solution.

Membrane evaporation for generating highly concentrated protein therapeutics

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Enfield, NH, United States of America

Austin Wayne Boesch