Merck Sharp + Dohme Corp.

Austin John Reeve

Leslie Joseph Street

Francine Sternfeld

Raymond Baker

Angus Murray MacLeod

Jose Luis Castro Pineiro

Sarah Christine Hobbs

William Robert Carling

Victor G Matassa

Mark Stuart Chambers

Victor Giulio Matassa

Graham A Showell

Alexander Richard Guiblin

Richard Alexander Jelley

Andrew Madin

Mark Stewart Chambers

Tamara Ladduwahetty

Kevin William Moore

Michael Geoffrey Russell

Howard Barff Broughton

Sylvie Bourrain

Ruth McKernan

Caroline Henry

Helen Routledge

A class of substituted imadazolo[2,1-a]phthalazine derivatives as ligands for GABAreceptors of formula I:which are partial or full inverse agonists of an &#x3b1;5 receptor subunit while being relatively free of activity at &#x3b1;1 and/or &#x3b1;2 and/or &#x3b1;3 receptor subunit binding sites are described herein; they are therefore of benefit as a medicament for enhancing cognition but with the reduction or elimination of proconvulsant activity.

Imidazolophthalazine derivatives as ligands for GABAA receptors

Substituted triazolo pyridazine derivatives as inverse agonists of the GABAA&agr;5 receptor subtype

1,2,4-triazolo&lsqb;4,3-b&rsqb;pyridazine derivatives are ligands for GABA,receptors useful in the treatment of disorders of dementing illnesses.

Therapeutically active 1,2,4-triazolo&lsqb;4.,3-B&rsqb; pyridazine derivatives as ligands for GABA receptors

A pharamceutical composition comprises a compound of formula (I) or a pharmaceutically acceptable salt thereof, wherein A is C,alkyl, C,alkenyl, C,-alkynyl, C,-cycloalkyl, arylC,alkyl, aryl, S(O),R,.

Thienycyclohexanone derivatives as ligands of the GABAA &agr;5 receptor subtype

Azetidine, pyrrolidine and piperidine derivatives as 5HT1 receptor

Substituted indolylpropyl-piperazine derivatives as 5-HT.sub.1D .alpha.

Substituted 1-indolylpropyl-4-phenethylpiperazadine derivatives

Azetidine, pyrrolidine and piperidine derivatives

Piperazine, piperidine and tetrahydropyridine derivative of

Imidazole, Triazole and tetrazole derivatives

A discrete class of 4-substituted 1,2,4-triazole derivatives are selective agonists of 5-HT.sub.1 -like receptors and are therefore useful in the treatment of clinical conditions, in particular migraine and associated disorders, for which a selective agonist of these receptors is indicated.

4-substituted 1,2,4-triazole derivatives

Imidazole, triazole and tetrazole derivatives

A class of indole-substituted five-membered heteroaromatic compounds are specific agonists of 5-HT.sub.1 -like receptors and are therefore useful in the treatment of clinical conditions, in particular migraine and associated disorders, for which a selective agonist of these receptors is indicated.

Indole-substituted five-membered heteroaromatic compounds as 5-HT.sub.1

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Great Dunmow, United Kingdom

Austin John Reeve