Baylor College of Medicine

Austin J Cooney

Vivek Singh

Megumi Mathison

Hongran Wang

Erin Lynn Reineke

Todd Rosengart

Vivekkumar B Patel

Vivek P Singh

Embodiments of the disclosure include methods and compositions for in situ cardiac cell regeneration, including transdifferentiation of cardiac cells to cardiomyocytes. In particular embodiments, in situ cardiac cell regeneration encompasses delivery of p63 shRNA and one or both of Hand2 and myocardin, and in specific embodiments further includes one or more of Gata4, Mef2c, and Tbx5. In specific aspects of the disclosure, adult cardiac fibroblasts are reprogrammed into cardiomyocytes using viral vectors that harbor p63 shRNA and one or both of the transcription factors Hand2 and myocardin.

p63 inactivation for the treatment of heart failure

Growing community of inventors

Houston, TX, United States of America

Austin J Cooney