Amgen Inc.

Austin G Smith

Liang Huang

Sheng Cui

Sebastien Caille

Jason S Tedrow

Robert Ronald Milburn

Philipp C Roosen

Alan H Cherney

Michael T Corbett

Oliver Thiel

Matthew G Beaver

John T Colyer

Ari Ericson

Padmini Kavuru Ananthoji

Peter Dornan

Kyle D Baucom

Xijie Dai

Gabrielle St-pierre

Rahul P Sangodkar

Michael A Lovette

Provided herein are processes for preparing Compound A or a salt thereof, comprising admixing Compound B or a salt thereof and crotonaldehyde in the presence of an acid catalyst and a solvent to form Compound A

Process for preparing 4-methyl-2-propan-2-yl-pyridine-3-carbonitrile

Provided herein are processes for synthesizing Mcl-1 inhibitors and intermediates such as compound F that can be used to prepare them where the variable PG is as defined herein. In particular, provided herein are processes for synthesizing compound A1, and salts or solvates thereof and compound A2, and salts and solvates thereof.

Ring closing synthesis of macrocyclic MCL-1 inhibitor intermediates

Provided herein are processes for synthesizing intermediates useful in preparing Mcl-1 inhibitors. In particular, provided herein are processes for synthesizing compound D, wherein OPG and Rare described herein. Compound D can be useful in synthesizing compound A1, or a salt of solvate thereof, and compound A2, or a salt of solvate thereof.

Synthesis of vinylic protected alcohol intermediates

The present invention provides commercial processes for preparing 2-((3R,5R,6S)-5-(3-chlorophenyl)-6-(4-chlorophenyl)-1-((S)-1-(isopropylsulfonyl)-3-methylbutan-2-yl)-3-methyl-2-oxopiperidin-3-yl)acetic acid as well as intermediates thereof.

Processes for preparing a MDM2 inhibitor

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CARY, NC, United States of America

Austin G Smith