University of California

Quidel Corporation

Alere San Diego, Inc.

Quidel Cardiovascular Inc.

Austin Derfus

Sangeeta N Bhatia

Michael J Sailor

Justin Davidson

Olaf Piepenburg

Paul Crivelli

Yang Yang Li

Kenneth S Vecchio

Armando R Tovar

Catherine Jean Greenwood

Ester Segal

Oliver Nentwich

Jason Dorvee

Karthikeyan Kumaravadivelu

Tuan Do

Alexander Schenk Zu Schweinsberg

Maulik Vinod Patel

Ji-Ho Park

Matthew Wang

Sara Alvarez

Benjamin Migliori

Lin Chao

Rebecca Campbell

Ulla Camilla Rang

Erik Mikael Olsson

Michael P Schwartz

A combination of components in a capillary flow channel use capillary forces to passively control the movement of liquid samples within a microfluidic device. To detect a target, a liquid sample introduced to a proximal portion of a capillary channel of a microfluidic device moves by capillary action along the specific components of capillary channel.

Microfluidic device, system and method

A microfluidic device includes an inlet port configured to receive a sample, a first reaction chamber fluidically coupled to the inlet port, a first pump fluidically coupled to the inlet port, a second pump fluidically coupled to a mixing chamber, a metering channel fluidically coupled to the first reaction chamber and to the mixing chamber, and one or more second reaction chambers fluidically coupled to the mixing chamber. The first pump is configured to move fluid from the inlet port to the first reaction chamber and from the first pump to the inlet port. The second pump is configured to move fluid from the second pump to the mixing chamber, from the first reaction chamber to the mixing chamber, and from the mixing chamber to the one or more second reaction chambers.

Microfluidic devices and related methods

The present invention uses externally applied electromagnetic stimulus to control and heat porous magnetic particles and material associated with the particles. The particles contain magnetic material, such as superparamagnetic iron oxide and are infused with a material. Application of a DC magnetic field allows them to be moved with their infused material, and application of an AC RF electromagnetic field allows them to be heated with their infused material. The material can be infused into pores of the particles and the particles can also adhere to an aqueous droplet. The present invention also provides a multi-layer porous magnetic particle. The particle includes a host layer having pores sized to accept magnetic nanoparticles. Magnetic nanoparticles are infused within pores of the host layer. An encoding layer includes pores that define a spectral code. The pores in the encoding layer are sized to substantially exclude the magnetic nanoparticles. The encoding layer can also be a multi-layer, exhibiting, for example, a complex spectral code.

Control of materials and porous magnetic particles

The invention includes sensors and sensing methods for determining cell morphology and/or chemical composition of an analyte. A porous substrate exhibiting a first optical signal is exposed to a target analyte and subsequently monitored for changes in the optical signal. More specifically, a photonic or porous substrate having a well-defined and highly tunable reflectivity or transmission spectrum, such as porous silicon (Si), porous alumina, porous Ge, porous GaAs, porous SiO2 and porous polymer, is used for example. A porous or photonic substrate is exposed to an analyte, such as a cell or other macromolecule, and changes in the scattered light are observed over time to determine cell morphology and/or chemical composition of the analyte using the substrate.

Porous photonic crystal with light scattering domains and methods of synthesis and use thereof

Growing community of inventors

Solana Beach, CA, United States of America

Austin Derfus