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Université De Limoges

Aurélie Lacroix

Fabrice Lalloue

Ludovic Micallef

Marie-Odile Jauberteau

Vincent Carre

Frédéric Varnat

Muriel Mathonnet

Disclosed is the in vitro use of at least one lectin which recognises the fucose alpha(1-2) galactose unit for labelling cancer stem cells of organs involved in respiration, in order to obtain labelled cancer stem cells of organs involved in respiration, in a biological sample. In one particular embodiment, the at least one lectin is chosen from the lectinsagglutinin 1 (UEA-1) or the homologue thereof,agglutinin II (TJA-II),agglutinin (ABA),agglutinin (ACA), jacalin, Griffonia Simplicifolia lectin I (GSL-I) and Griffonia Simplicifolia lectin II (GSL-II). In one particular embodiment, the organ involved in respiration is chosen from the lungs, the larynx, the pharynx, the mouth, the nose, the throat, the tongue, the sinuses, the trachea and the saliva glands including the tonsils and the parotid gland.

Method of isolating and detecting cancer stem cells

Disclosed is the in vitro use of at least one lectin for marking cancer stem cells of hormone-dependent cancer target organs, selected from the lectinslectin II (MAH-II),lectin (EEL),lectin I (PTL-I) andlectin II (GSL-II), in particular at least two lectins selected from MAH-II, EEL, PTL-I and GSL-II, in particular the two lectins MAH-II and EEL, in order to obtain cancer stem cells of labeled hormone-dependent cancer target organs in a biological sample.

Method for isolating and detecting cancer stem cells

The invention relates to the use of a lectin that recognizes the fucose &#x3b1; 1-2 galactose unit, as a first means for labeling and optionally a second means for labelling colorectal cancer stem cells, in particular a lectin that recognizes the T antigen, in order to carry out a method for the detection and optionally isolation of colorectal cancer stem cells, a method for the detection and optionally isolation of colorectal cancer stem cells for research purposes, and a method for the in vitro diagnosis of colorectal cancer recurrence risk and/or aggressiveness so as to define a prognostic value in order to make colorectal cancer therapy adjustments, as well as a kit comprising a lectin that recognizes the fucose &#x3b1; 1-2 galactose unit and a lectin that recognizes the T antigen.

Method for isolating cancer stem cells

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Panazol, France

Aurélie Lacroix