Ecole Polytechnique Federale De Lausanne

Bruker Biospin Ag

Ecole Polytechnique Féderale De Lausanne (Epfl)

Aurélien Bornet

Geoffrey Bodenhausen

Sami Jannin

Frank Engelke

Antonio Giuseppe Gianotti

Joost Lohman

Roberto Melzi

Roberto Buratto

Nicola Salvi

A method for producing hyperpolarized sample material for use in magnetic resonance investigations involves preparing a target material containing high &#x3b3; nuclei with a short T, a polarizing agent with a broad EPR line, and low &#x3b3; nuclei with a long T. The polarizing agent in the target material is irradiated with microwave radiation, wherein the target material is at a cryogenic temperature and exposed to a static magnetic field B&#x2267;4.0 T, thus polarizing the high &#x3b3; nuclei by DNP, and the polarization is transferred from the high &#x3b3; nuclei to the low &#x3b3; nuclei by Cross Polarization. A dissolved sample material is prepared containing the hyperpolarized low &#x3b3; nuclei from the target material. Nuclei with a long longitudinal relaxation time Tcan thereby be quickly hyperpolarized to a high polarization level.

MRI compatible method and device for rapid DNP on a solid state hyperpolarized sample material

A method for nuclear magnetic resonance (NMR) spectroscopy of a sample involves excitation of long lived coherences (LLC) between the singlet state Sand the central triplet state Tof nuclei of the sample by initiating irradiation of the sample with an rf-field with carrier frequency &#x3c9;; sustaining of the LLC by maintaining the rf-irradiation during an interval &#x3c4;; converting the LLC temporarily into observable magnetization by interrupting the rf-irradiation during an observation interval &#x3c4;; detecting NMR-signals during the observation interval &#x3c4;and reconversion of the observable magnetization back into LLC after the observation interval &#x3c4;. These steps are repeated n times, wherein n is a positive integer. The method allows ultra high-resolution spectra of long-lived coherences to be obtained.

Method for NMR spectroscopy with sustained induction decays of long-lived coherences

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Haute-Nendaz, Switzerland

Aurélien Bornet