Institut National De La Sante Et De La Recherche Medicale

Hospices Civils De Lyon

Calixar

Université Claud Bernard Lyon 1

Centre National De La Recherche Scientifique

Universite Claude Bernard – Lyon1

Ecole Normale Superieure De Lyon

Inserm

Aurélien Traversier

Eric Samain

Manuel Rosa-Calatrava

Emmanuel Dejean

Élodie Desuzinges-Mandon

Manuel Rosa-calatrava

Emeline Richard

The present invention relates to a method for preparing a vaccine antigen, which includes a step of fragmenting a biological membrane associated with said vaccine antigen by treating said biological membrane with at least one calixarene of formula (II): wherein: X is a &#x2014;(CH2)-CO2Y group and Y is an alkaline metal or one of the pharmaceutically acceptable salts thereof, wherein said resulting vaccine antigen also includes a fragment of the biological membrane associated with said antigen. The present invention also relates to a vaccine that can be produced by implementing the method, including a calixarene of formula (II) in carrier format, with a quantity of 0.1 to 1,000 &#x3bc;g in the total weight of the vaccine. The present invention further relates to the use of a calixarene as defined above for the preparation of a vaccine or a vaccine antigen, and to the vaccine for use as a drug in the treatment or prevention of an infectious disease. 

Method for preparing a vaccine antigen, resulting vaccine antigen and uses

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Vénissieux, France

Aurélien Traversier