Idenix Pharmaceuticals, Inc.

Merck Sharp + Dohme Corp.

Aurélien Salanson

David Dukhan

Jean-Laurent Paparin

John D Schreier

Gilles J Gosselin

Cyril B Dousson

Izzat Tiedje Raheem

Timothy John Hartingh

Houcine Rahali

Gilles Gosselin

Guillaume Brandt

Daniel Da Costa

Rachid Rahali

François-René Alexandre

Compounds of Formula (I): (Formula (I)) and their pharmaceutically acceptable salts are useful for the inhibition of HIV reverse transcriptase. The compounds may also be useful for the prophylaxis or treatment of infection by HIV and in the prophylaxis, delay in the onset or progression, and treatment of AIDS. The compounds and their salts can be employed as ingredients in pharmaceutical compositions, optionally in combination with other antiviral agents, immunomodulators, antibiotics or vaccines. 

Antiviral aryl-amide phosphodiamide compounds

Provided herein are compounds, compositions and methods for the treatment of Flaviviridae infections, including HCV infections. In certain embodiments, compounds and compositions of nucleoside derivatives are disclosed, which can be administered either alone or in combination with other anti-viral agents. In certain embodiments, the compounds are 3'-substituted methyl or alkynyl nucleosides of Formula I: (I); or a pharmaceutically acceptable salt, solvate, stereoisomeric form, tautomeric form or polymorphic form thereof, wherein Base, PD, R, R, R, Rand Z are as defined herein. 

3'-substituted methyl or alkynyl nucleosides nucleotides for the treatment of HCV

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Montpellier, France

Aurélien Salanson