Sofradim Production

Aurelie Serrero

Suzelei Montanari

Mylene Desorme

Robert Vestberg

Amandine Jaillon

The present invention relates to a method for preparing a chitosan-based matrix () comprising the following steps: The invention also relates to an implant comprising a matrix obtained according to such a method.

Method for preparing a chitosan-based matrix comprising a fiber reinforcement member

The present invention relates to an implant () comprising:

Implant comprising oxidized cellulose and method for preparing such an implant

The present invention relates to an implant () comprising: &#x2014;a substrate () the surface of which comprising oxidized cellulose, said oxidized cellulose having a degree of oxidation ranging from 0.0 to 1, and &#x2014;a multilayer coating covering said substrate, said multilayer coating comprising at least a first layer () adjacent said substrate, said first layer being formed of chitosan, and a second layer () adjacent said first layer, said second layer being formed of oxidized cellulose having a degree of oxidation ranging from 0.5 to 1. The invention further relates to a method for preparing such an implant.

The present invention relates to a method for preparing a chitosan-based matrix comprising the following steps:

The present invention relates to a method for preparing a neutralized matrix of non-antigenic collagenous material comprising the steps of: &#x2014;a) preparing an acidic solution of non-antigenic collagenous material, &#x2014;b) pouring the solution of a) into a mold in order to form a layer, &#x2014;c) lyophilizing the layer of b) in order to obtain an acidic matrix of non-antigenic collagenous material, d) sterilizing the acidic matrix obtained in c) with ethylene oxide in order to obtain a neutralized matrix of non-antigenic collagenous material. The invention also relates to the matrices obtained and to surgical implants comprising such matrices.

Method for preparing neutralized matrix of non-antigenic collagenous material

The present invention relates to a haemostatic patch comprising a porous layer based on oxidized cellulose and a neutralized film based on chitosan, said film comprising a free face and a face fixed on one of the faces of the porous layer, and to the method of preparing said patch comprising the following steps: &#x2014;a&#xb0;) preparing a porous layer based on oxidized cellulose, &#x2014;b&#xb0;) preparing a film based on chitosan starting from an acidic aqueous solution of chitosan, &#x2014;c&#xb0;) fixing the film obtained in b&#xb0;) on one face of the porous layer, &#x2014;d&#xb0;) neutralizing the film obtained in b&#xb0;), &#x2014;where step c&#xb0;) can be carried out before or after step d&#xb0;), characterized in that: the neutralizing step d&#xb0;) comprises treatment of said film with a neutralizing composition comprising at least ethanol and ammonium hydroxide (NHOH).

Haemostatic patch and method of preparation

Implants include a film layer containing cellulose secured to a surface of the porous layer that also contains cellulose, wherein the film layer is secured to the porous cellulose without the use of an adhesive.

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Lyons, France

Aurelie Serrero