Bracco Imaging S.p.a.

Aurelia Ferrigato

Fulvio Uggeri

Luciano Lattuada

Roberta Fretta

Pier Lucio Anelli

Attilio Citterio

Massimo Visigalli

Valeria Boi

Pierfrancesco Morosini

Sonia Gazzetto

Gabriella Leonardi

Silvia Ceragioli

Roberta Mazzon

Laura Orio

Armando Mortillaro

Evelin Vignale

Gabriele Meli

Andrea Barale

Pier Francesco Morosini

Daniela Giardina-Papa

The invention relates to a process for the one-step preparation and isolation of a protected DO3A such as DO3A-tri-tert-butyl ester as a solid salt.

Manufacturing of protected DO3A

The present invention discloses a process for the preparation of gadobenate dimeglumine complex in a solid form. In particular, said solid form is conveniently obtained by spray-drying a corresponding liquid suspension at a given temperature and concentration. The present invention is particularly advantageous for the industrial scale as the solid form may be obtained by employing water as a solvent, which is a non-toxic solvent, easy to handle and basically not requiring troublesome health or safety precautions.

Process for the preparation of gadobenate dimeglumine complex in a solid form

The present invention relates to a process for the preparation of iodinated anilines; in particular, it relates to a process including the direct iodination, with suitably activated iodine, of 3,5-disubstituted anilines to the corresponding 3,5-disubstituted-2,4,6-triiodoanilines, which are useful intermediates for the synthesis of x-ray contrast media, and to the preparation of the contrast media themselves. 

Process for the iodination of aromatic compounds

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Trecate, Italy

Aurelia Ferrigato