Louisiana State University and Agricultural & Mechanical College

National Institutes of Health, a Component of the US Dept. of Health & Human Services

National Institutes of Health (nih)

Nih Division of Extramural Inventions and Technology Resources (deitr)

Augusto C Ochoa

Paulo Cesar Rodriguez

Timothy Paul Foster

James Milton Hill

Mohamed Ghonim

Hamid Boulares

Amir Al-Khami

The invention is directed to roles for PARP-1 in disease.

PARP-1 and methods of use thereof

Provided are compositions and methods of use thereof that modulate C/EBP homologous stress-related protein (Chop) activity in Myeloid-derived Suppressor Cells (MDSCs). Chop is a key point in the response of MDSCs to tumor-generated stress factors. In turn, the MDSCs release cytokines and other factors that function as immune suppressors, thereby allowing the tumors to thrive and expand. By inhibiting the level of Chop activity, the immunosuppressive function of MDSCs is disrupted. It has also been unexpectedly found that there is a concomitant increase in the ability of MDSCs to act as antigen-presenting and cytokine producing cells so as to act in increasing the efficacy of anti-tumor immune-based therapies.

Compositions and methods for reducing C/EBP homologous protein activity in myeloid-derived suppressor cells

Methods and therapeutic treatments of diseases such as viral infections are provided including applying peg-Arginase I. Methods are provided that treat inflammation mediated diseases with peg-Arginase I.

Methods for treatment of inflammatory and infectious viral diseases

Methods and therapeutic treatments of ocular diseases are provided including applying peg-Arginase I to affected eyes. Methods are provided that simultaneously treat inflammation and neovascularization of eyes while promoting healing. Methods are provided to treat lesions or infections of an eye.

Growing community of inventors

New Orleans, LA, United States of America

Augusto C Ochoa