Linxis B.v.

Augustinus A M S Van Dongen

Hendrik Jan Houthoff

Niels Jurriaan Sijbrandi

Dennis Christian Johannes Waalboer

Robbert Jan Kok

Sytze Jan Buwalda

A first aspect of the disclosure relates to a method for preparing cell-targeting conjugates by coupling at least one functional moiety, such as a therapeutic compound, diagnostic compound or chelating agent to a targeting moiety. A second aspect of this disclosure relates to the cell-targeting conjugates obtainable with this method. A third aspect of the disclosure described herein relates to pharmaceutical compositions comprising the cell-targeting conjugates.

Method for preparing cell targeting conjugates, and the complexes obtained

This disclosure describes a method for preparing stable cell targeting conjugates. A further aspect of this disclosure relates to the stable cell targeting conjugates obtainable by the method and to pharmaceutical compositions comprising these stable cell targeting conjugates. A last aspect of this disclosure relates to the use of these conjugates and pharmaceutical compositions as a medicament.

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Utrecht, Netherlands

Augustinus A M S Van Dongen