Agilent Technologies, Inc.

August Jon Hidalgo

John Christian Fjeldsted

William Daniel Frazer

Carl A Myerholtz

Ken Poulton

Gregory Steven Lee

Kenneth Lawrence Staton

Gangqiang Li

Robert Keith Crawford

Stuart Carl Hansen

Gregor T Overney

William H McAllister

George Stennis Moore

Randall Scott Urdahl

May Tom-Moy

Randy Keith Roushall

Brian D Setterberg

James Edward Cooley

Martin L Guth

Bryan David Miller

Christian A LeCocq

Michael Manlove

A plasma generation device includes: a substrate having a first surface and a second surface; a stripline resonant ring disposed on the first surface of the substrate, and defining a discharge gap; a pair of electrode extensions connected to the stripline resonant ring at the discharge gap; a ground plane disposed on the second surface of the substrate; a gas flow element configured to flow gas between at least one of: (1) the discharge gap, and (2) the pair of electrode extensions; and a structure disposed adjacent the substrate to form an enclosure that substantially encloses at least a region including the discharge gap and the electrode extensions, the enclosure being adapted to contain a plasma.

Plasma generation device with split-ring resonator and electrode extensions

A detection signal generated in response to incident ions accelerated at temporally-irregular intervals having an average repetition rate greater than a reference repetition rate represents detection events each having an event time and an intensity. For each detection event, respective allowed TOFs between the event time and the transient times are calculated. Using respective initial probabilities, initial apportionments of the intensity of each detection event among the allowed TOFs linked thereto are determined. For each allowed TOF, the intensity apportionments thereto are accumulated to generate an intensity accumulation linked thereto. For each detection event, respective revised probabilities are iteratively determined using the intensity accumulations linked to the allowed TOFs linked thereto, and the respective intensity is iteratively reapportioned among the allowed TOFs linked thereto using the revised probabilities to transform the detection signal to a time-of-flight spectrum.

Dithered multi-pulsing time-of-flight mass spectrometer

A method and apparatus for performing time of flight mass spectrometry wherein the number of sums of transients taken for generating a given spectra is determined as a function of a characteristic of the incoming data for that spectrum. For instance, the number of transient measurements taken for a given spectrum output can be determined as a function of the abundance of ions in the sample or the abundance of ions corresponding to a base peak or another selected peak. In yet another embodiment, the collection of transients is terminated when a threshold signal to noise ratio is attained.

Time of flight mass spectrometry method and apparatus

A mass spectrometer comprises an ion detector, an analog-to-digital (A/D) converter, a sample adjuster, and an adder. The A/D converter is configured to generate digital samples representing an analog signal received from the ion detector during a mass scan. The adder is configured to sum the samples with corresponding unsuppressed samples representing analog signals received from the ion detector during previous mass scans, the summed samples defining a mass spectrum. The sample adjuster is configured to identify a peak defined by the samples and to suppress all but one of the samples defining the identified peak to enhance resolution of a peak in the mass spectrum.

Mass spectrometer and method for enhancing resolution of mass spectra

A mass spectrum is generated by a process in which, from a mass scan signal comprising original samples defining a peak, a subset of the original samples defining the peak is selected. One or more synthesized samples are synthesized from the subset of the original samples. The one or more synthesized samples provide a temporal resolution greater than the temporal resolution of the original samples. The one or more synthesized samples are summed with respective temporally-aligned accumulated samples to produce the mass spectrum. The accumulated samples are obtained from mass scan signals generated during respective previously-performed mass scan operations.

Enhanced resolution mass spectrometer and mass spectrometry method

A system for detecting ions is disclosed. The system includes a detector having a plurality of dynodes arranged in an electron cascading configuration, and a power supply circuit electrically coupled to the plurality of dynodes. The plurality of dynodes include a first dynode and a second dynode. The power supply circuit is arranged to selectively adjust a potential difference between the first and second dynodes between a detection mode and a blanking mode. A method of detecting ions is also disclosed.

Electron multiplier having electron filtering

A mass spectrometer includes an ion detector, an analog-to-digital (A/D) converter, and a decimator. The analog-to-digital (A/D) converter is configured to receive and sample an analog signal from the ion detector thereby providing a first plurality of samples at a first rate. The decimator is configured to receive the first plurality of samples and to transmit, at a second rate, a second plurality of samples that are based on the first plurality of samples. The decimator is further configured to dynamically adjust the second rate so that memory requirements for the mass spectrometer are reduced.

Systems and methods for dynamically adjusting sampling rates of mass spectrometers

Methods and apparatus for electronically addressing and interrogating microarrays are disclosed. The described microarrays include a plurality of features disposed on a substrate. Each of the features has a first electrode disposed on the substrate, a second electrode disposed on the substrate, and a probe disposed between the first electrode and second electrode. The substrate also includes addressing circuitry in operable relation to the features. Method of using the microarrays are also described.

Electronically readable microarray with electronic addressing function

A mass spectrometer system includes an ion detector, a plurality of analog-to-digital (A/D) converters, an adder, and a controller. The A/D converters are configured to sample an analog signal from the ion detector at different times, and the A/D converters introduce sampling errors to digital samples generated by the A/D converters. The adder is configured to sum the digital samples, and the summed digital samples define a mass spectrum. The controller is configured to compensate for the sampling errors introduced by the A/D converters.

Mass spectrometer and method for compensating sampling errors

A mass spectrometer comprises an ion detector, a first amplifier, a second amplifier, and a spectra combiner. The ion detector is configured to generate an analog signal indicative of ions detected by the ion detector. The first amplifier is configured to amplify the analog signal to provide a first amplified signal having a first gain relative to the analog signal. The second amplifier is configured to amplify the analog signal to provide a second amplified signal having a second gain relative to the analog signal, and the first gain is different than the second gain. The spectra combiner is configured to combine first summed digital samples of the first amplified signal with second summed digital samples of the second amplified signal.

Mass spectrometer and method for enhancing dynamic range

A mass spectrometer comprises an ion detector, an analog-to-digital (A/D) converter, a sample adjuster, and an adder. The A/D converter is configured to receive and sample an analog signal from the ion detector thereby providing a plurality of samples. The adder is configured to sum the samples, and the summed samples define a mass spectrum. The sample adjuster is configured to identify a peak defined by the samples and to suppress at least one of the samples of the peak such that a resolution of a peak within the mass spectrum is enhanced.

Improved data acquisition systems and methods that enable large numbers of data samples to be accumulated rapidly with low noise are described. In one aspect, a data acquisition system includes an accumulator that has two or more parallel accumulation paths and is configured to accumulate corresponding data samples across a transient sequence through different accumulation paths.

Multipath data acquisition system and method

An apparatus for analyzing ions is described. The apparatus includes an ion source, an ion trap positioned to receive ions from the ion source; a time of flight mass analyzer, and a detector operatively coupled to the time of flight. The time of flight mass analyzer includes a pulser region, and the pulser region is positioned to receive ions from the ion trap. The apparatus further includes a scanning delay timing circuit in operable relation to the pulser region. The scanning delay timing circuit is adapted to triggering an extraction pulse at the pulser region. Methods of analyzing ions by mass spectrometry are also described.

Ion trap mass spectrometer with scanning delay ion extraction

A mass spectrometer having an ion accelerator and an ion detector utilizing a finite impulse response filter is disclosed. The ion accelerator generates an ion pulse in response to a start signal. A clock increments a register that indicates the time that has elapsed since the start signal. The ion detector is spatially separated from the ion accelerator and generates a measurement signal indicative of ions striking the detector. The measurement signal is filtered through a finite impulse response filter to form a filtered measurement signal. The finite impulse response filter has a filter function that depends on the impulse response of the ion detector. In one embodiment, the mass spectrometer includes a memory that is addressed by the register value and an adder. The adder forms the sum of the data value specified by the register value and the output value from the finite impulse response filter.

Time-of-flight mass spectrometry utilizing finite impulse response filters to improve resolution and reduce noise

A spectrometer having a reduced memory size. The spectrometer has an address register, a detector for generating a digital measurement, first and second memories and an adder. The first memory stores data words having a value less than a maximum value, at the register defined address. The adder adds the data value on the data bus to the digital measurement to generate a sum value that is divided into a low order part having a value less or equal to the maximum value and an overflow value. The second memory stores at least a portion of the sum value at a location specified by the register value if the overflow value is greater than zero.

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San Francisco, CA, United States of America

August Jon Hidalgo