Napo Pharmaceuticals, Inc.

Shaman Pharmaceuticals, Inc.

Napo Pharmaceutcials, Inc.

Atul S Khandwala

Gul P Balwani

Edward James Rozhon

Akram Sabouni

Jody Wai-Han Chan

David F Sesin

Edward J Rozhon

Pharmaceutical compositions containing a proanthocyanidin polymer composition which are useful for the treatment and prevention of secretory diarrhea are provided. The invention specifically relates to pharmaceutical formulations of a proanthocyanidin polymer composition which has been isolated from aspp. or aspp. In particular, the invention relates to a formulation of a proanthocyanidin polymer composition which protects the composition from the effects of stomach acid after oral administration, particularly to those formulations which are enteric coated. The invention also relates to methods of producing a directly compressible proanthocyanidin polymer composition, as well as compositions containing the directly compressible proanthocyanidin polymer composition.

Compositions and methods of treatment with proanthocyanidin polymer antidiarrheal compositions

Method of treating secretory diarrhea with enteric formulations of proanthocyanidin polymer

Enteric formulations of proanthocyanidin polymer antidiarrheal compositions

This invention is directed to methods for treatment of non-insulin-dependent diabetes mellitus, for reducing blood glucose levels, or hyperglycemia. The methods entail administering to a mammal in need of such treatment a therapeutically effective amount of a composition whose active ingredient consists essentially of a compound of the following structure or a pharmaceutically acceptable salt thereof: ##STR1## In the compound R and R' are independently H or a C.sub.1 -C.sub.20 alkyl or C.sub.2 -C.sub.20 alkenyl group which may be substituted or unsubstituted. Alternatively, R and R' are such that together a cycloalkyl or cycloalkenyl ring is formed. In the chain linking the two phenolic derivatives each of (C(R).dbd.C(R')) or (C(R)(R')) are the same or different. A and A' are independently C.sub.2 -C.sub.20 acylamino, C.sub.2 -C.sub.20 acyloxy, C.sub.2 -C.sub.20 alkanoyl, C.sub.2 -C.sub.20 alkoxycarbonyl, C.sub.1 -C.sub.20 alkoxyl, C.sub.1 -C.sub.20 alkyl amino, C.sub.2 -C.sub.20 alkyl carboxyl, amino, C.sub.2 -C.sub.20 carbalkoxyl, carboxyl, cyano, halo, hydroxy. B and B' are independently H, C.sub.2 -C.sub.20 alkanoyl, C.sub.3 -C.sub.20 alkenoyl, C.sub.2 -C.sub.20 alkenyl, C.sub.2 -C.sub.20 alkoxycarbonyl, C.sub.1 -C.sub.20 alkyl, aroyl, aralkanoyl, C.sub.2 -C.sub.20 carbamoyl, or phosphate. The invention is also directed to methods of treatment using a bisphenolic compound in conjunction with another hypoglycemic or hypolipidemic agent.

Use of bisphenolic compounds to treat type II diabetes

Growing community of inventors

San Carlos, CA, United States of America

Atul S Khandwala