Baxter International Inc.

Atul R Khare

Lecon Woo

Daniel R Boggs

Shmuel Sternberg

Michael T K Ling

Craig L Sandford

William S Hurst

Patrick T Ryan

Algirdas J Bindokas

Scott D Edwards

Henk P Blom

Julian Breillatt

Mark Conrad Jones

James H Brauker

Robin Gail Pauley

Laura A Martinson

Steven K Neuenfeldt

Donna L McLarty

The present invention provides a flowable material container assembly having a membrane tube disposed coaxially within a port tube. The membrane tube has an outer layer, a core layer, and an inner layer. The outer layer is a blend of a polyolefin and a thermoplastic elastomer. The core layer is a blend of a polyolefin and a thermoplastic elastomer. The inner layer is a blend of a polyolefin, a radio frequency susceptible polymer, and a thermoplastic elastomer.

Port tube and closure composition, structure and assembly for a flowable material container

The present invention provides a flowable material container closure assembly having a port tube and a membrane tube. The port tube (I) has a first layer and a second layer, (A) the first layer is a polymer blend and (B) the second layer is disposed coaxially within the first layer; and the membrane tube (II) is disposed coaxially within the port tube, the membrane tube has an outer layer, a core layer and an inner layer.

Port tube closure assembly

A device and method for inactivating pathogens in therapeutic fluids with sterilizing radiation in a continuous thin fluid flow arrangement that exhibits radiation dose uniformity for fluids having high optical densities. Radiation dose uniformity is achieved in part through a &ldquo;carrying&rdquo; mechanism that moves or carries the fluid, thereby eliminating a channel flow velocity profile where flow volumes near the channel walls run the risk of overexposure to the radiation due to very large residence times within the channel. The device comprises a relatively flat belt chamber ( ) connected to a fluid flow through an inlet ( ) and an outlet ( ) on the belt chamber ( ). The belt chamber ( ) has a top surface ( ) and a bottom surface ( ). A radiation permeable plate ( ) is disposed adjacent the top surface ( ) of the belt chamber ( ) and is in contact with the belt chamber ( ). A radiation source ( ) is provided adjacent to the plate ( ) adjacent to a side opposite the belt chamber ( ). A belt ( ) having a plurality of flexible vanes ( ) is disposed adjacent the bottom surface ( ) of the belt chamber ( ) such that the vanes ( ) make contact with the belt chamber ( ). The belt is driven by a roller mechanism ( ) in the direction of the fluid flow. As the fluid flows through the belt chamber ( ), the flexible vanes ( ) provide a squeegee-like mechanism to move the fluid through the belt chamber ( ) in discrete packets ( ) defined by a pair of vanes ( ). As the packets of fluid move through the belt chamber, they are exposed to sterilizing radiation passing through the plate ( ).

Device and method for pathogen inactivation of therapeutic fluids with sterilizing radiation

A device and method for inactivating pathogens in therapeutic fluids with sterilizing radiation in a continuous flow arrangement while exhibiting radiation dose uniformity and narrow residence time distribution of the fluid within the device. The device ( ) comprises a radiation permeable cylindrical tube ( ) having a concentric cylindrical rotor ( ) disposed therein, thereby providing a thin gap ( ) therebetween. A top plate ( ) having a fluid outlet ( ) and a bottom plate ( ) having a fluid inlet ( ) seal the cylindrical tube ( ). The inlet ( ) and outlet ( ) are both in fluid communication with the thin gap ( ). A rotor shaft ( ) is disposed axially through the cylindrical rotor ( ) and is connected to a motor ( ). A pump provides fluid flow through the device ( ). A radiation source provides sterilizing radiation to the fluid through the cylindrical tube ( ). As the fluid flows, the motor ( ) drives the rotor ( ) to impart Taylor vortices to the fluid flow, which exchanges the fluid closer to the cylindrical tube ( ) with the fluid closer to the rotor ( ).

A permeable structure forms a chamber to hold living cells. The structure includes a first permeable region surrounding at least a portion of the chamber having a conformation that, when implanted in host tissue, substantially blocks penetration of host cells into the chamber while permitting solute transport. The structure also includes a second permeable region overlying the first permeable region having a conformation that, when implanted in host tissue, forms a permeable interface with host tissue that permits solute transport. A third permeable region is located between the first and second permeable regions. The third region comprises a solution of polymer material formed in place between the first and second permeable regions. The third permeable region bonds the first and second permeable regions together. The third permeable region also has a conformation that, when implanted in host tissue, permits solute transport between the first and second permeable regions. The third, formed-in-place region bonds the first and second permeable regions together, providing a robust, laminated structure that resists delamination during implantation caused by cellular infiltration into discontinuous spaces between the first and second regions. The third, formed-in-place region can also have a conformation providing an immunoisolation effect. Furthermore, the permeability of the third, formed-in-place membrane is sufficient high that it does not adversely effect the permeability value desired for the overall multiple layer membrane structure.

Multiple-layer, formed-in-place immunoisolation membrane structures for

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Crystal Lake, IL, United States of America

Atul R Khare