Council of Scientific and Industrial Research

Atul Kumar

Suprabhat Ray

Girish Kumar Jain

Man Mohan Singh

Sangita

Puvvada Sri Ramanchandra Murthy

Abhishek Kumar Singh

Anil Kumar Rastogi

Naibedya Chattopadhyay

Anju Puri

Sabyasachi Sanyal

Srikanta Kumar Rath

Arun Kumar Trivedi

Anil Kumar Tripathi

Nidhi Singh

Dipak Datta

Tahseen Akhtar

Devdutt Chaturvedi

Shailendra Kumar Dhar Dwivedi

Reema Rastogi

Manisha Yadav

Arivend Srivastava

Priti Tewari

Rehan Ahmad

Jawahar Lal

Bandana Chakravarti

Ramaesh Chander

Geetika Bhatia

Jay Sharan Mishra

Farhar Rivizvi

Puvvada Sri Ramchandra Murthy

The present invention relates to substituted aryl naphthyl methanone oximes of general formula (I), their process for preparation and their derivatives, salts, pharmaceutical composition thereof and their use in treatment of chronic myelogenous leukemia, acute myelogenous leukemia, lymphoma, multiple myeloma, solid tumor forming cell-lines including such as breast cancer, endometrial cancer colon cancer, prostate cancer and killing of drug resistant cancer stem cells, as subject in need thereof. 

Aryl naphthyl methanone oxime(s) and process for preparation thereof

Novel mercaptophenyl naphthyl methane compounds, their pharmaceutically acceptable salts and compositions comprised thereof are useful for the prevention or treatment of various medical indications associated with estrogen dependent diseases or syndromes related to osteoporosis, bone loss, bone formation, cardiovascular disorders, neurodegenerative disorders, menopausal disorders, physiological disorders, diabetes disorders, prostatic carcinoma, cancer of breast, cancer of uterus, cancer of the cervix and cancer of the colon, threatened or habitual abortion, obesity, ovarian development or function, post-partum lactation and depression.

Mercaptophenyl naphthyl methane compounds and synthesis thereof

The present invention relates to compounds of the formula I in which substituents Rand Rare arranged in trans-configuration: wherein: wherein Y is chosen from NHR, NR, NHCOR, NHSOR, CONHR, CONR, CONR, COOH, COOR, SOR, SOR, SONHR, SONR, a C3-C7 heterocyclic ring, saturated or unsaturated, containing one or two heteroatoms independently selected from the group consisting of O, S and N, optionally being substituted with 1 to 3 substituents independently selected from the group comprising H, OH, halogen, nitro, cyano, SH, SR, trihalo-C1-C6-alkyl, C1-C6-alkyl and C1-C6-alkoxy, preferably NHR, NR, or a nitrogen heterocycle, wherein Ris as defined above, and the esters, ethers, and salts of the compounds of formula I, optionally along pharmaceutically acceptable excipients, a process for the preparation of the same, and a method of preventing and/or treating estrogen-related disease conditions in a subject using compounds of formula 1, or its salts, optionally along with pharmaceutically acceptable excipients.

(3R, 4R)-trans-3, 4-diarylchroman derivatives and a method for the prevention and/or treatment of estrogen dependent diseases

This invention relates to novel {overscore (&#x3c9;)}-substituted-naphthyloxy-amino alkanes, their preparation and use as antihyperglycemic agents and for the treatment and prevention of cardiovascular disorders (CVS) such as lipid lowering effects.

Alpha-substituted naphthyloxy omega-substituted alky/aryl amino-substituted alkane derivatives as agent for treatment or prophylaxis of diabetes and related metabolic disorders

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Lucknow, India

Atul Kumar