Northwestern University

The Boeing Company

University of Illinois

Atul D Jain

Gary E Schiltz

Sarki A Abdulkadir

Huiying Han

David Arthur Whelan

Rama K Mishra

Javier Izquierdo-Ferrer

Terry D Moore

Brian J David

Phillip Lazzara

Benjamin Richardson

Disclosed are substituted heterocycle compounds including substituted pyrazoles, substituted pyrimidines, and substitute triazoles. The substituted heterocycles disclosed herein are shown to be useful in inhibiting c-MYC and may be utilized as therapeutics for treating cancer and cell proliferative disorders.

Substituted heterocycles as c-MYC targeting agents

Disclosed are proteolysis-targeting chimeric molecules (PROTACs) that induce degradation of c-MYC protein. The disclosed PROTACs typically include a first targeting moiety that binds to c-MYC (M) which may be derived from a substituted heterocycle that binds to c-MYC such as a substituted pyrazole. The first targeting moiety typically is linked via a bond or a linker (L) to a second targeting moiety that binds to an E3 ubiquitin ligase (M). As such, the disclosed PROTACS may be described as having a formula M-L-Mor M-L-M.

Proteolysis-targeting chimeric molecules (PROTACs) that induce degradation of c-MYC protein

Disclosed herein are compounds that can act as inhibitors of the Kelch-like ECH-associated protein 1/nuclear factor (erythroid-derived 2)-like 2 ('KEAP1/NRF2') protein-protein interaction, and methods of using the compounds to treat and prevent diseases and disorders, such as COPD, multiple sclerosis, and diabetes, and in the promotion of wound healing. The compounds described herein can include compounds of Formula (I) and pharmaceutically acceptable salts thereof: formula (I), wherein the substituents are as described. 

1,4-substituted isoquinoline inhibitors of KEAP1/NRF2 protein-protein interaction

Systems, methods, and apparatus for transmitting and receiving signals are disclosed. In one or more embodiments, the disclosed method involves splitting a signal into low power portions. The method further involves coding the low power portions to produce coded low power portions, where the coding comprises convolving each low power portion with a respective different code. Also, the method involves summing the coded low power portions to produce a resultant coded signal. In addition, the method involves transmitting the resultant coded signal towards a target object. Additionally, the method involves receiving a reflected resultant coded signal, where the resultant coded signal reflects off the target object to produce the reflected resultant coded signal. Also, the method involves decoding the reflected resultant coded signal to produce a decoded signal. Further, the method involves correlating the decoded signal to produce a complete received signal.

Multicode transmitter

A particular method includes splitting a signal into multiple portions corresponding to elements of an array. The method also includes coding and phase adjusting the multiple portions of the signal to form phase adjusted, coded portions of the signal by coding each portion of the multiple portions with a different code and by applying phase adjustments associated with the corresponding elements of the array to the portions. The method also includes transmitting the phase adjusted, coded portions of the signal via the corresponding elements of the array.

Coded aperture scanning

Systems and methods according to one or more embodiments provide for a multicode transmitter/receiver that acts like a high power array when a correlated receiver is used, but acts as a collection of small low gain transmitters when an uncorrelated receiver is used. In one embodiment, a method of transmitting and receiving signals comprises splitting a signal into more than one portion for feeding the signal into separate elements of an array; coding each portion of the signal for transmission through each separate element of the array with a different code respectively; transmitting each coded portion of the signal through a corresponding separate element of the array; receiving the coded portions of the signal by at least one element on a receiver side; decoding the coded portions of the signal; and adding decoded portions of the signal to form a complete received signal.

Growing community of inventors

Chicago, IL, United States of America

Atul D Jain