Astrazeneca Ab

Cancer Research Technology Limited

Dizal (Jiangsu) Pharmaceutical Co., Ltd.

Dizal Pharmaceutical Co., Limited

Attilla Kuan Tsuei Ting

Frederick Woolf Goldberg

Maurice Raymond Verschoyle Finlay

Jason Grant Kettle

Gillian McGregor Lamont

David Buttar

Martin Richard Howard

The specification generally relates to compounds of Formula (I): (I) and pharmaceutically acceptable salts thereof, where R, A, Aand Ahave any of the meanings defined herein. The specification also relates to the use of such compounds and salts thereof to treat or prevent DNA-PK mediated disease, including cancer. The specification further relates to pharmaceutical compositions comprising such compounds and salts; kits comprising such compounds and salts; methods of manufacture of such compounds and salts; intermediates useful in the manufacture of such compounds and salts; and to methods of treating DNA-PK mediated disease, including cancer, using such compounds and salts.

Purinone compounds and their use in treating cancer

The invention concerns compounds of Formula (I):

Triazolopyrimidine compounds and their use in treating cancer

The specification generally relates to compounds of Formula (I): and pharmaceutically acceptable salts thereof, where Rand Rhave any of the meanings defined herein. The specification also relates to the use of such compounds and salts thereof to treat or prevent DNA-PK mediated disease, including cancer. The specification further relates to pharmaceutical compositions comprising such compounds and salts; kits comprising such compounds and salts; methods of manufacture of such compounds and salts; intermediates useful in the manufacture of such compounds and salts; and to methods of treating DNA-PK mediated disease, including cancer, using such compounds and salts.

Amino-triazolopyridine compounds and their use in treating cancer

The invention concerns compounds of Formula (I): 

Growing community of inventors

Cambridge, United Kingdom

Attilla Kuan Tsuei Ting