Chinoin Gyogyszer Es Vegyeszeti

Alkaloida Vegyeszeti Gyar Tiszavasvari

Attila Zoltai

Jozsef Knoll

Sandor Makleit

Laszlo Litkei

Istvan Gyoker

Gyorgy Toth

Sandor Elek

Terez Mile

Geza Kiss

Sandor Berenyi

Rezso Bognar

Reszo Bognar

Azidoethylmorphine, a new 7,8-dihydroisomorphine derivative, has excellent antitussive effects without respiration depression.

7,8-Dihydroisomorphine derivative, namely azidoethylmorphine

A process for the preparation of pharmaceutically acceptable 3-protected derivatives of 6-deoxy-6-azido-14-hydroxy-7, 8-dihydroisomorphine, selected from the group which consists of 3-O-acetyl-6-deoxy-6-azido-14-hydroxy-7, 8-dihydroisomorphine, 3-O-tetrahydropyranyl-6-deoxy-6-azido-14-hydroxy-7, 8-dihydroisomorphine and 3-O-methylenemethoxy-6-deoxy-6-azido-14-hydroxy-7, 8-dihydroisomorphine, and the salts of these compounds which comprise the following steps:

6-Deoxy-6-azido-14-hydroxy-7,8-dihydroisomorphine or a pharmaceutically

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Attila Zoltai