Chinoin Gyogyszer Es Vegyeszeti Termekek Gyara Rt.

Astra Aktiebolag

Sanofi-synthelabo

Aktiebolaget Astra

Attila Nemeth

Csaba Huszar

Ferenc Sperber

Dezso Korbonits

Pal Kiss

Gergely Heja

Endre Palosi

Ida Szvoboda Nee Kanzel

Csaba Gonczi

Laszlo Ledniczky

Erzsebet Molnar Nee Bako

Erzsebet Szalay

Istvan Bone

Ferenc Morasz

Karoly Ban

Gyorgy Mihalovics

Karol Gyure

Erzsebet Szabo Nee Kardos

Sandor Garaczy

Eva Somfai

Attila Kis-Tamas

Antal Gajary

Lajosne Pali

Mihaly Su

Iren Pali Nee Ivanics

Iidiko Buttkai

Arpad K Vari

Peter Gy Ri

Mihaly Sut

Peter Gyri

Ildiko Buttkai

Arpad Kvari

Process for the preparation of imidazolones

Process for the preparation of 4-methyl-5-(2-chloroethyl)-thiazole and

The present invention relates to a process for the preparation of compounds of general formula (I), wherein R stands for a straight chained C.sub.1-5 alkyl group substituted by a chlorine atom in the 2-position, and acid addition salts thereof, characterized by reacting a 3,5-dichloro-2-alkanone of general formula (V), wherein R is a defined above, with an inorganic thiocyamate, and a) converting the 3-thiocyanato-5-chloro-2-alkanone of general formula (IV), thus obtained, wherein R is as defined above, into 2-chloro-4-methyl-5-(2-chloroalkyl)-thiazole of general formula (II), wherein R is as defined above, by gaseous hydrochloric acid in an organic solvent, hydrogenating the said compound in the presence of a metal catalyst in an organic solvent, or b) reacting said compound of general formula (IV) with an aqueous mineral acid and treating the 2-hydroxy-4-methyl-5-(2-chloroalkyl)-thiazole of general formula (III), thus obtained with a halogenating agent, and hydrogenating the 2-chloro-4-methyl-5-(2-chloroalkyl)-thiazole of general formula (II) thus obtained, wherein R is as defined above, in an organic solvent in presence of a metal catalyst, and optionally converting the 4-methyl-5-(2-chloroalkyl)-thiazole of general formula (I), wherein R is as defined above, thus obtained or a hydrochloride salt thereof, in a manner known per into another acid addition salt or setting free a compound of general formula (I), wherein R is a defined above, from its acid addition salt.

The present invention is directed to the preparation of benzimidazole derivatives of the formula (I), ##STR1## wherein A=stands for S, SO or SO.sub.2,

Chemical process for the preparation of pharmaceutically active compounds

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God, Hungary

Attila Nemeth