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Atta-Ur Rahman

Muhammad Iqbal Choudhary

Khalid Mohammed Khan

Atia-Tul Wahab

Humera Jahan

Saba Farooq

Sammer Yousuf

Shabana Usman Simjee

Farzana Shaheen

M Iqbal Choudhary

Sheikh Riazuddin

Javed Akram

Usman Ashfaq

Zulfiqar Ali Khan

Humaira Zafar

Nimra Naveed Shaikh

Mehwish Manzoor

Osman Ali

Shaheen N Khan

Ajmal Khan

Nida Ambreen

Zehra Batool

Mahwish Siddiqui

Farzana Naz

Zarbad Shah

Christian D A Fozing

Biotransformation of an aromatase inhibitor, testolactone (1), yielded four metabolites, 7β-hydroxy-3-oxo-13,17-seco-5β-androsta-1-eno-17,13α-lactone (2), 3α,11β-dihydroxy-13,17-seco-5β-androsta-17,13α-lactone (3), 4β,5β-epoxy-3β-hydroxy-13,17-secoandrosta-1-eno-17,13α-lactone (4), and 4β,5β-epoxy-3α-hydroxy-13,17-secoandrosta-1-eno-17,13α-lactone (5). Aromatase (estrogen synthase) involves in the synthesis of estrogen, and promotes the growth of breast cancerous cells. It is a key target for the discovery of chemotherapeutic agents against ER+(estrogen-positive) breast-cancers. Metabolites 2 (IC=8.63±0.402 nM), and 3 (IC=9.23±1.31 nM) were identified as potent inhibitors against human aromatase enzyme, in comparison to 1 (IC=0.716±0.031 μM), and the standard aromatase inhibiting drug, exemestane (IC=0.232±0.031 μM). Derivatives 4 (IC=10.37±0.50 μM) and 5 (IC=0.82±0.059 μM) also showed a good inhibition against aromatase enzyme. Therefore, metabolites 2-5 have the potential to serve as therapeutic agents against ER+ (estrogen-positive) breast-cancers.

Potent aromatase inhibitors through fungal transformation of anti-cancer drug testolactone: an approach towards treatment of breast cancer

A nasally administered liquid, including suspension and viscous liquid compositions, containing a therapeutically effective quantity of (Z)-2-(3,5,5-trimethyl-2-cyclohexen-1-ylidene) acetic acid, its salts or analogs, combined with suitable pharmaceutical ingredients, to treat epilepsy.

Nasally administered pharmaceutical composition for the treatment of epilepsy and related disorders

A food supplement to reduce symptoms of Parkinson's disease is disclosed. The food supplements contains a mixture of garlic, almond, peanut, tomato, grape, clove, black eye pea turmeric, tea and velvet bean.

Food supplement to alleviate symptoms of Parkinson's disease

The current study established that treatment of diabetes using compound 1(2,4-dinitroanilino-benzoic acid), an anthranilic acid derivative, by restoring the functional activities of the pancreas via its insulinotropic action.

2, 4-dinitroanilino-benzoic acid: novel insulinotropic agent for the treatment of diabetes

One embodiment of the invention relates to treating diseases associated with increased urease enzyme activity comprising administering an effective amount of a compound selected from a group consisting of 28 thiazoles Schiff bases. Kinetic studies were performed on ten (10) of the most active compounds.

Schiff bases of thiazoles: a new class of ureases inhibitors

The invention relates to methods of inhibiting the protein glycation process and the associated formation of Advanced Glycation End products (AGEs) in hyperglycemia by administering 6-Nitrobenzimidazole derivatives. These derivatives were found to be effective not merely against the formation of AGE, but they can inhibit the action of AGEs at post-receptor levels.

Inhibitors of advanced glycation end-products (ages)formation

Two thiourea derivatives N-(3-chlorophenyl)-N'-(3,4-difluorophenyl)thiourea and N-(3-chlorophenyl)-N-(3-methoxyphenyl)-thiourea are reported as treatment of multidrug resistance infections from

Thiourea derivatives

Artonin I is reported to treat multi-drug resistantinfections.

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Surprising antiviral activity of 3-amino-2-(4-nitrophenyl)-4-(3H)-quinazolinone (Compound 1) was reported in the treatment or prevention of viral infections, particularly in combination with other antiviral agents such as interferon and/or ribavarin.

3-amino-2-(4-nitrophenyl)-4-(3H)-quinazolinone or derivatives thereof for treating or preventing antiviral infections

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Karachi, Pakistan

Atta-Ur Rahman