Kyoto University

Takeda Pharmaceutical Company Limited

National Cancer Center Japan

Thyas Co. Ltd.

Atsutaka Minagawa

Shin Kaneko

Tetsuya Nakatsura

Hiroshi Kawamoto

Kyoko Masuda

Akitsu Hotta

Yasushi Uemura

Yutaka Yasui

Kyoko Fukuda

Yoshiaki Kassai

Toshiaki Yoshikawa

Atsushi Matsuda

Yutaka Shimazu

Hiroshi Ichise

Provided is a method for inducing T cells for a cell-based immunotherapy, comprising the steps of:

Method for inducing t cells for cell-based immunotherapy from pluripotent stem cells

Provided is a T cell receptor capable of binding to a peptide having the amino acid sequence shown in SEQ ID NO: 27 or a complex of the peptide and HLA-A24. A T cell receptor capable of binding to a peptide having the amino acid sequence shown in SEQ ID NO: 28 or a complex of the peptide and HLA-A02. Disclosed T cell receptors are useful in treating or avoiding cancers which are associated with expression of glypican-3.

T-cell receptor

The present invention provides a method for efficiently inducing CD8-positive T cells by adding vitamin C to the medium in the steps of induction of the CD8-positive T cells from pluripotent stem cells. The present invention also provides a method for efficiently inducing CD8-positive T cells by performing culture in a medium supplemented with an adrenocortical hormone agent in the step of induction of the CD8-positive T cells from CD4/CD8 double-positive T cells.

Method for induction of T cells from pluripotent stem cells

Growing community of inventors

Kyoto, Japan

Atsutaka Minagawa