Shimadzu Corporation

Atsushige Ikeda

Tohru Shiohama

Hideki Yamamoto

Hiroaki Kozawa

Minoru Fujimoto

Under the control of an analysis control unit (), a mass spectrometer unit () performs a product-ion scan measurement for a target component in a target sample within a time range where the component is introduced. It also performs a scan measurement over an m/z range including the m/z of an ion originating from a standard component within the same segment of time. A mass correction information calculator () calculates mass correction information from measured and theoretical values of the m/z of the ion originating from the standard component observed on an MS spectrum obtained by the scan measurement. Using the mass correction information, a mass corrector () corrects the m/z of each ion peak originating from the target component observed on an MS/MS spectrum obtained by the product-ion scan measurement performed within the same cycle as the scan measurement concerned. It is possible to consider that the MS measurement and the MS/MS measurement within the same cycle have been almost simultaneously carried out. Accordingly, a mass correction which is almost equivalent to an internal standard method can be achieved.

Tandem mass spectrometer

A reference value selection unit selects a reference value that lies in a predetermined margin from reference sample data corresponding to a set reference sample. A data acquisition unit acquires mass spectrum data in a data acquisition range including a set analysis range and the margin. A data correction unit corrects the mass spectrum data based on the reference value and a measured value on the reference sample in the data acquisition range. When no reference value lies in the margin, the reference value selection unit selects a reference value that lies outside the analysis range but closest to the margin. The data acquisition unit acquires mass spectrum data in a data acquisition range expanded to allow the reference value to lie in the data acquisition range. The data correction unit corrects the mass spectrum data based on the reference value and the measured value in the data acquisition range.

Growing community of inventors

Kyoto, Japan

Atsushige Ikeda