Daiichi Sankyo Company, Limited

Atsushi Tengeiji

Masahiro Ikeda

Takashi Shimada

Kazumasa Aoki

Yoshihiro Shibata

Kazuki Yano

Katsuhiro Kawakami

Satoru Ohsuki

Kentoku Gotanda

Toshihiro Kiho

Chikahiro Nagata

Compounds or pharmacologically acceptable salts thereof for promoting osteogenesis, improving bone metabolism, preventing or treating bone fracture, preventing or treating a disease associated with bone metabolism, or in the field of orthopedics for the promotion of healing of bone fracture, a bone defect, and bone diseases such as osteoarthritis as well as in the field of dentistry for the treatment of periodontal disease and the stabilization of artificial tooth root. The compounds are represented by formula (I) or a pharmacologically acceptable salt thereof: 

Chromone derivative having osteogenesis promoting effect

Problem to be Solved To provide a novel compound inhibiting the effect of HSP90, in particular a novel compound inhibiting the function of HSP90 as a chaperone protein and having antitumor activity. Solution The present invention provides a pyrazolopyrimidine compound represented by the formula (1) having various substituents which inhibits the ATPase activity of HSP90 and which has antitumor activity, an HSP90 inhibitor comprising the compound represented by the formula (1), a medicament comprising the compound represented by the formula (1), an anticancer agent comprising the compound represented by the formula (1), a pharmaceutical composition comprising the compound represented by the formula (1) and a method for treating cancer using the compound represented by the formula (1). 

Pyrazolopyrimidine derivative

Growing community of inventors

Kawasaki, Japan

Atsushi Tengeiji