Eisai R&d Management Co., Ltd.

Atsushi Takemura

Richard S Clark

Osamu Asano

Nobuhisa Watanabe

Masanobu Shinoda

Fumiyoshi Matsuura

Kazunobu Kira

Hiroshi Azuma

Shinsuke Hirota

Tadashi Nagakura

Takao Omae

Kimiyo Tabata

Kazutomi Kusano

So Yasui

Masaki Mikamoto

By oral administration of a compound represented by the following Formula (I): the blood level of Compound (IV): which has an excellent inhibitory action against blood coagulation factor VIIa and the anticoagulant action, reaches a level sufficient for expression of its pharmacological actions. Therefore, the compound of the present invention is useful as a therapeutic and/or prophylactic agent for diseases caused by thrombus formation. 

Prodrug of triazolone compound

A compound represented by the following general formula (1), or a salt thereof has serine protease inhibiting activity, and particularly excellent inhibiting activity against clotting factor VIIa. This compound or a salt thereof is useful as therapeutic and/or prophylactic agents for diseases associated with thrombus formation. [wherein Rrepresents hydrogen, Rrepresents optionally substituted phenyl, etc., Rrepresents optionally substituted C6-10 aryl, etc.].

2,3-dihydro-iminoisoindole derivatives

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Ibaraki, Japan

Atsushi Takemura