Canon Kabushiki Kaisha

Keio University

Kao Corporation

Toagosei Company, Ltd.

Atsushi Takayanagi

Nobuyoshi Shimizu

Toshifumi Fukui

Nobuhiro Tomatsu

Tetsuhiko Yoshida

Atsushi Yamagishi

Nubuhiro Tomatsu

Michiyo Okui

A probe, a set of probes, and a probe carrier on which the probe or the set of probes is immobilized, are provided for classification of fungus species. The probe or the set of probes is capable of collectively detecting fungus of the same species and distinguishingly detecting those fungus from fungus of other species. The probe is an oligonucleotide probe for detecting a pathogenic fungus DNA and includes at least one of base sequences of SEQ ID NOS. 1 to 3 and mutated sequences thereof.

Probe, probe set, probe carrier, and testing method

A cell growth inhibitor that includes, as an antibody component, an artificially produced anti-EGFR antibody having specific binding capacity to EGFR which is characterized in that an epitope therefor is in a cysteine-rich subdomain 2 (C2 domain) and/or in a ligand-binding domain 1 (L1 domain) among four subdomains contained in the extracellular domain of EGFR.

Anti-EGFR antibody and use thereof

A probe, a set of probes, and a probe carrier on which the probe or the set of probes is immobilized, are provided for classification of fungus species. The probe or the set of probes is capable of collectively detecting fungus of the same species and distinguishingly detecting those fungus from fungus of other species. The probe is an oligonucleotide probe for detecting a pathogenic fungus DNA and includes at least one of base sequences of SEQ ID NOS. 1 to 4 and mutated sequences thereof.

The present invention provides an oral cavity composition with which brief treatment using the same yields a high effect for dental cavity prevention and an excellent dental hyperesthesia preventive and treatment effects, and a method of treatment using such a composition. The oral cavity composition according to the present invention contains a first composition (A) containing a fluoride ion-supplying compound, an inorganic phosphoric acid and a salt thereof, and a second composition (B) containing a calcium salt of organic acid, with an organic acid constituting said calcium salt of organic acid having a pKa value ranging from 3 to 11, or at least one pKa value ranging from 3 to 11 when said organic acid has plural pKa values, wherein said first composition (A) and said second composition (B) are discretely packed from each other so that said two compositions can be alternately used and then come to be mixed with each other at a tooth region when applied thereto.

Oral cavity composition

A probe, a set of probes, and a probe carrier on which the probe or the set of probes is immobilized, are provided for classification of fungus species. The probe or the set of probes is capable of collectively detecting fungus of the same species and distinguishingly detecting those fungus from fungus of other species. The probe is an oligonucleotide probe for detecting a pathogenic fungus DNA and includes at least one of base sequences of SEQ ID NOS. 1 to 2 and mutated sequences thereof.

An artificial antibody library with a super-repertory (10or more) is constructed by: using a cDNA library as a template, amplifying a fragment containing the CDR1 and CDR2s regions of the VH or VL region of immunoglobulin gene and a fragment containing the CDR3 region each by the PCR method; integrating the VH library and the VL library, which are little contaminated with unexpressionable repertory and have high safety, into an non-expression vector; transferring it into a host; and then shuffling the VH region in the VH library with the VL region in the VL library.

Growing community of inventors

Tokyo, Japan

Atsushi Takayanagi