Okayama University

Atsushi Takano

Kenji Sasaki

Hiroki Kakuta

Kayo Takamatsu

Nobumasa Yakushiji

Kazunori Morohashi

Kenichi Morishita

Disclosed is a compound represented by the general formula shown below, which can bind to a retinoid X receptor (RXR), which is one of nuclear receptors, and exhibit an agonistic or antagonistic action. [Wherein, Ris selected from the group consisting of an alkyl group, an alkenyl group, an alkynyl group and an aryl group. Ris selected from the group consisting of an alkoxy group, an alkyl group, an alkenyl group, an alkynyl group and an aryl group. W is NRor CR; and Ris selected from a hydrogen, an alkyl group, an alkenyl group, an alkynyl group and an aryl group. Xand Yare selected from CH or N. Xand Yare selected from CH, CRor N. Ris selected from an alkyl group, an alkenyl group, an alkynyl group, an alkoxy group, a halogen, a nitro group and an amino group. Z is selected from a carboxylic acid, a carboxylate ester or a hydroxamic acid, which is bound directly or via an alkyl group, an alkenyl group or an alkynyl group.] 

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Okayama, Japan

Atsushi Takano