Ono Pharmaceutical Co., Ltd.

Atsushi Shimabukuro

Kaoru Kobayashi

Atsushi Naganawa

Fumio Nambu

Maki Iwahashi

Seiji Ogawa

Koji Yano

Atsushi Kinoshita

Yutaka Okada

Yoko Kishida

Shouji Kawauchi

Kohki Tsukamoto

Yoko Matsunaga

Kousuke Tani

Akihiro Kinoshita

Takahiro Nekado

Keisuke Hanada

Yoshiyuki Aratani

A compound that can be a therapeutic agent for underactive bladder which has low risk of side effects and can be administered orally is provided. Furthermore, a crystal which is advantageous in view of the stability, long-term storage, handleability, easiness of the drug preparation or the like as a drug substance of medicaments is provided. Since a salt of 2-[(2-{(1R,5R)-2-oxo-5-[(1E,4S)-7,8,8-trifluoro-4-hydroxy-4-methyl-1,7-octadien-1-yl]cyclopentyl}ethyl)thio]-1,3-thiazole-4-carboxylic acid or a diastereomeric mixture thereof and 4-piperidinemethanol is a chemically very stable crystal, it can be stored for a long time, and is very useful as a drug substance of medicaments.

Amine salt and crystals thereof

Carboxylic acid compounds and medicinal compositions containing the same as the active ingredient

Growing community of inventors

Mishima-gun, Japan

Atsushi Shimabukuro