Yoshitomi Pharmaceutical Industries, Ltd.

Mitsubishi Pharma Corporation

Yamasa Shoyu Co., Ltd.

Atsushi Sakai

Toshiyuki Shibata

Kenji Chiba

Shinji Sakata

Tadashi Mishina

Takanori Miyashita

Tsuneo Fujii

Kazuhiko Kondo

Rumiko Masuda

Takayuki Ogawa

Kyouichi Hirotsu

Hirotsugu Tada

Medicinal compositions which can be processed into solutions and are useful in inhibiting rejection reactions against the transplantation of organs or bone marrow, in the maintenance immunotherapy therefor or in treating autoimmune diseases, characterized by containing 2-amino-2-&lsqb;2-(4-octylphenyl)ethyl&rsqb;propane-1,3-diol or pharmaceutically acceptable acid-addition salts thereof and cyclodextrins as a stabilizer optionally together with saccharides, if required.

Pharmaceutical composition

An antitumor composition for oral administration, comprising a 2'-deoxy-2'-methylidenecytidine compound of the formula ##STR1## wherein R is a hydrogen or a halogen, and R.sup.1 and R.sup.2 are the same or different and each is a hydrogen, a halogen or an alkyl having 1 to 4 carbon atoms, an acid addition salt thereof or a hydrate thereof, and a sucrose ester of fatty acid(s). The pharmaceutical composition of the present invention comprising a DMDC compound useful as an antitumor agent based on its remarkable degenerative action on solid tumor shows an improved oral absorption.

Antitumor composition for oral administration

Novel stable, non-hygroscopic 2'-deoxy-2'-methylidenecytidine dihydrate and its methods for production, and compositions with improved solubility containing same and saccharide(s).

2'-deoxy-2'-methylidenecytidine dihydrate, methods for its production

Growing community of inventors

Fukuoka, Japan

Atsushi Sakai