Kureha Corporation

Globeride, Inc.

Atsushi Saitou

Masahiro Ono

Shigeru Suzuki

Mikiro Yanaka

Shigeyuki Kikumoto

Ryo Matsui

Toru Yamazaki

Kunitaka Hirose

Yoshiyuki Takemura

Haruka Takahashi

Sei Kumakura

Hiroyuki Mori

Masaru Akiba

Masayuki Watanabe

Masashi Yamamoto

Eiji Sugaya

Tomohiro Sawa

Hideyuki Naitou

Tomoyoshi Turufuji

A set of fishline guides which are configured to be attached to a rod in an axial direction of the rod, each of the set of fishline guides includes a frame including a fixing portion configured to be attached to an outer surface of the rod, a ring holding portion to which a guide ring through which a fishline passes is attached, and a support leg connecting the fixing portion to the ring holding portion, the fixing portion being in a plane transverse to a plane of the ring holding portion. The frame includes a plurality of fiber-reinforced resin layers foamed by laminating a plurality of fiber-reinforced prepregs in which a reinforcing fiber is impregnated with a synthetic resin. A normal line to a plane of each of the fiber-reinforced resin layers forming the ring holding portion coincides with an axial direction of the ring holding portion.

Fishline guide

Amine compounds represented by Formula () are efficacious against diseases such as a viral infectious disease with HIV, rheumatism, and cancer metastasis: 

Amine-based compound and use thereof

It is intended to provide novel amine compounds which are efficacious against diseases such as infection with HIV virus, rheumatism and cancer metastasis. Namely, amine compounds represented by the following general formula (1):  In a typical case, A1 and A2 represent each an optionally substituted monocyclic or polycyclic aromatic heterocycle; W represents cyclic C3-10 alkylene, an optionally substituted monocyclic or polycyclic aromatic heterocycle, a monocyclic or polycyclic aromatic ring or a partly saturated polycyclic aromatic ring; X represents O, CH2, C(&#x2550;O) or NR11; and D is a group represented by the following general formula (4) or (6).  In the formula (6), Q represents a single bond, S, O or NR12; and Y is a group represented by the following general formula (7). z represents an optionally substituted monocyclic or polycyclic aromatic ring. In the formula (6), B represents NR25R26. In the above formulae, R1 to R26 each represents hydrogen, alkyl, alkenyl or alkynyl.

Amine compound and use thereof

Novel amine compounds which are efficacious against diseases such as infection with HIV virus, rheumatism, and cancer metastasis include compounds represented by the following general formula (1), a pharmacologically acceptable salt thereof, or a prodrug thereof: wherein each of n, n, and nis an integer of 1; each of R, R, R, R, R, and Ris independently a hydrogen atom; Ais imidazole; Ais imidazole or imidazole substituted with an alkyl group; W is a phenyl group or naphthyl group; X is CH; D is a group represented by -Q-Y&#x2014;B, wherein Q is NRand Ris a hydrogen atom or an alkyl group; Y is (CH)mand mis an integer of 2 to 4; and B is N(RR), wherein each of Rand Rare independently a hydrogen atom, a C&#x2013;Calkyl group or a C&#x2013;Ccycloalkyl group.

Amine compounds and use thereof

Growing community of inventors

Tokyo, Japan

Atsushi Saitou