Fuji Photo Film Company, Limited

Atsushi Orikasa

Naoyuki Nishikawa

Ichiro Azuma

Masayoshi Kojima

Hiroyuki Komazawa

Ikuo Saiki

Mitsunori Ono

Yoshihisa Tsukada

Hideto Mori

Hiroshi Kitaguchi

Hideaki Satoh

There are disclosed amino acid derivatives represented by the following general formula (I): ##STR1## wherein L.sup.1 and L.sup.2 represent an amino acid residue etc., A.sup.1 and A.sup.3 represent C.dbd.O, A.sup.2 represents an alkylene group etc., m and n represent an integer of 1 to 5, V represents --NHC(.dbd.NH)NH.sub.2 etc., W represents --COOH etc., R.sup.1 and R.sup.2 represent hydrogen atom, alkyl group etc., R.sup.3 and R.sup.4 represent hydrogen etc. and X and Y represent --NH-- or --O-- and pharmaceutically acceptable salts thereof and agents for inhibiting tumor matastasis containing the compounds, and the amino acid derivatives exhibit high activity for inhibiting tumor metastasis and weak platelet aggregation inhibition activity and weak anticoagulation activity.

Amino acid derivatives and application thereof

A peptide derivative containing 1 to 20 units of peptide unit represented by the following general formula [I] or a pharmaceutically acceptable salt thereof;

Tumor metastasis inhibiting compounds and methods

A peptide-containing polyethylene glycol derivative represented by the following general formula [I] or [II]: ##STR1## wherein each R.sup.1 independently represents a peptide residue represented by the following general formula [IIIa] or [IIIa]:

Peptide-containing polyethylene glycol derivatives and application

Growing community of inventors

Minami-ashigara, Japan

Atsushi Orikasa