Kao Corporation

Atsushi Ohuchi

Shigeru Moriwaki

Naoko Tsuji

Yasuto Suzuki

Hiroshi Kusuoku

Shingo Kakuo

Genji Imokawa

Yoshinori Nishizawa

Akira Hachiya

Yoshinori Takema

Mitsuyuki Hotta

Susumu Ichinose

Hideshi Kidena

Akemi Kobayashi

A method of increasing expression of the aromatase gene by treating a cell population with an effective amount of an aromatase activator containing an extract of, where the effective amount ranges from 0.0001 to 1% by weight based on the total weight of the aromatase activator on a dry basis.

Aromatase activator

Drugs and cosmetics which are highly safe, and which are effective in preventing, improving, or treating various pathological conditions caused by estrogen depletion are provided. Provided are aromatase activators containing at least one member selected from plants such as Labiatae sps. including(huangcen),(jingjie), sage, lavender,, and thyme, an extract thereof; yeast extract; silk protein extract; milk protein; trehalose; natto extract; royal jelly;oil; hydrolyzated wheat extract; shea butter; and rice fermentation extract.

This invention relates to depilatories and external preparations, each of which contains endothelin or its agonist, and also to a depilating method characterized by administering endothelin or its agonist. As the depilatories and external preparations according to the present invention inhibit growth of hair in mammalian skin, their application to the human body as drugs or cosmetics permits safe and effective removal of hair from the body. These depilatories and external preparations are also usable as wool harvesting preparations.

Depilatories and agents for external use

treating method for hair growth inhibition, which comprises administering (A) the extract of a plant of the family Juniperus or a malt. In addition, the present invention relates to a dermatologic composition for external use, which comprises (B) an elastase inhibitor or neutral endopeptidase inhibitor, and the above-described component (A) and/or (C) at least one proteolytic enzyme selected from the group consisting of papain, trypsin, chymotrypsin, pepsin, bromelain, ficin and pancreatin.

Treating method for suppressing hair growth

The present invention is directed to an aromatase activating agent containing a plant selected from among mulberry bark, ginseng, cucumber, andbark; or; or an extract of any of these ingredients. The aromatase activating agent of the present invention is highly safe to the human body, and useful as a drug or cosmetic composition for prevention, amelioration, or treatment of various lesions caused by estrogen deficiency.

Method for treating lesions caused by estrogen deficiency with extract of cucumber

The present invention relates to a treating method for hair growth inhibition, which comprises administering (A) the extract of a plant of the family Juniperus or a malt. In addition, the present invention relates to a dermatologic composition for external use, which comprises (B) an elastase inhibitor or neutral endopeptidase inhibitor, and the above-described component (A) and/or (C) at least one proteolytic enzyme selected from the group consisting of papain, trypsin, chymotrypsin, pepsin, bromelain, ficin and pancreatin.

Disclosed herein are a method of inhibiting hair growth, which comprises administering an inhibitor of elastase-like enzymes or a neutral endopeptidase inhibitor, and use of an inhibitor of elastase-like enzymes or a neutral endopeptidase inhibitor for the preparation of a hair-growth inhibitor.

Method of inhibiting hair growth

The present invention relates to flavanonol derivatives represented by formula (1): ##STR1## (wherein R.sup.1 represents an alkyl group, and each of R.sup.2 and R.sup.3 represents a hydrogen atom, an alkyl group which may have a substituent, an alkoxyl group which may have a substituent, a hydroxyl group, a cyano group, or a halogen atom), as well as to hair-nourishing and hair-growing compositions containing the derivatives. The compounds accelerate differentiation and proliferation of hair matrix cells, thereby exhibiting remarkable hair-nourishing and hair-growing effects.

Growing community of inventors

Tochigi, Japan

Atsushi Ohuchi