Mitsubishi Tanabe Pharma Corporation

Atsushi Numata

Hiroyuki Furukawa

Tomohiro Yoshida

Maiko Hamada

Hiroshi Sakashita

Naoto Fujie

Junki Ando

Masayuki Watanabe

Hiroyuki Ushio

Tooru Takashima

Saori Tahara

Hisashi Kawasumi

The present invention relates to a novel amide derivative. More specifically, the present invention provides a medicinal agent useful as a prophylactic or therapeutic agent for diseases, which relies on the production of cytokines from T cells, and which comprises an amide derivative or a pharmacologically acceptable salt thereof or a solvate of the derivative or the pharmacologically acceptable salt as an active ingredient. Provided is an amide derivative represented by general formula (I) [wherein each symbol is as defined in the description] or a pharmacologically acceptable salt thereof, or a solvate of the derivative or the pharmacologically acceptable salt.

Amide derivative and use thereof

The invention provides a sulfonyl malonamide derivative, or a pharmacologically acceptable salt thereof or a solvate thereof, that has therapeutic and/or preventive effects(s) on various diseases due to its agonist action at ATreceptor, and is useful as a pharmaceutical agent for the treatment and/or prevention of diseases involving the renin-angiotensin-aldosterone system (RAAS).

Malonic acid sulfonamide derivative and pharmaceutical use thereof

Growing community of inventors

Osaka, Japan

Atsushi Numata