Chugai Seiyaku Kabushiki Kaisha

Atsushi Narita

Tomoyuki Igawa

Takahiro Ishiguro

Junichi Nezu

Yumiko Kawai

Naoka Hironiwa

Hirotake Shiraiwa

Mika Sakurai

Taichi Kuramochi

Akihisa Sakamoto

By replacing the antigen-binding domain, the present inventors discovered novel polypeptide complexes that retain BiTE's strong anti-tumor activity and excellent safety properties, as well as have long half-life in blood and can damage various different target cells.

Cytotoxicity-inducing therapeutic agent

Multi specific antigen-binding molecules maintaining excellent cellular cytotoxicity and high stability, which comprise a domain that contains an antibody variable region having glypican 3-binding activity and a domain that contains an antibody variable region having T-cell receptor complex-binding activity are provided. Since the provided molecules show a strong cytotoxicity against cells and tissues expressing glypican 3, it is possible to produce pharmaceutical compositions for treating or preventing various cancers.

Novel multispecific antigen-binding molecules maintaining excellent cellular cytotoxicity and high stability, which comprise a domain that contains an antibody variable region having glypican 3-binding activity and a domain that contains an antibody variable region having T-cell receptor complex-binding activity, were discovered. Since the molecules of the present invention show a strong cytotoxicity against cells and tissues expressing glypican 3, it is possible to produce novel pharmaceutical compositions for treating or preventing various cancers.

Cytotoxicity-inducing theraputic agent

Growing community of inventors

Shizuoka, Japan

Atsushi Narita