Public University Corporation Yokohama City University

Saga University

Kyoto Prefectural Public University Corporation

Kohjin Life Sciences Co., Ltd.

Otsuka Pharmaceutical Company, Limited

Keio University

Mitsubishi Pencil Kabushiki Kaisha

Ibaraki University

Ayabo Corporation

Biofermin Pharmaceutical Co., Ltd.

National Institute for Materials

Atsushi Nakajima

Takaomi Kessoku

Susumu Saito

Yoshio Sumida

Yuichiro Eguchi

Yusuke Sauchi

Kazuhiko Furukawa

Hiroshi Ohno

Keizo Tsukamoto

Masaki Shimakawa

Hiroyuki Muto

Yoshiki Tanaka

Mitsuhiro Ohashi

Hiroyuki Gunji

Naoyuki Hirata

Toshihiro Ando

Masahide Tona

Tomohiro Kawahara

Mika Uno

Hironori Tsunoyama

Koji Fujita

Masato Yoneda

Osamu Mukeda

Takako Ichimura

Nanoclusters are produced in a gas phase using a nanocluster manufacturing section including: a vacuum container; a sputtering source that has a target as a cathode, performs magnetron sputtering by pulse discharge, and generates plasma; a pulse power source that supplies pulsed power to the sputtering source; a first inert gas supply section that supplies a first inert gas to the sputtering source; a nanocluster growth cell that is contained in the vacuum container; and a second inert gas introduction section that introduces a second inert gas into the nanocluster growth cell. A multitude of supports are rolled in the gas phase and each of the supports is sprinkled with a multitude of nanoclusters to cause each support to support the multitude of nanoclusters.

Support body, manufacturing apparatus for support body, and manufacturing method for support body

An object of the present invention is to provide a composition for preventing or improving fat deposition on the liver in spite of the alcohol intake history of a level that a liver disease is not caused. The inventors found that glutathione has an effect of preventing or improving fat deposition on the liver, which is not caused by alcohol, and completed the present invention. Among nonalcoholic fat diseases, the present invention is particularly effective in an early stage of the treatment or in a case where treatment for another disease is not performed.

Composition for improving or preventing nonalcoholic fatty liver

An object of the present invention is to provide an agent for preventing or treating a fat-associated disease and/or inflammation. The present invention provides an agent for preventing or treating a fat-associated disease and/or inflammation, the agent comprising abacterium or a processed product thereof.

Agent for preventing or treating fat-associated diseases and/or inflammation

The invention relates to a medicament for preventing and/or treating fatty liver which comprises as an active ingredient cilostazol or a pharmaceutically acceptable salt thereof.

Carbostyril derivatives including cilostazol for treating fatty liver

There is provided a ballpoint pen tip in which a shoulder of a bent portion does not touch a paper surface during writing and bleeding caused by deformation of an inner periphery of the bent portion can be prevented, and an ink refill using thereof. The ballpoint pen tipcomprises a first tapered surfaceformed by tapering an outer periphery at a front end of a holdera connecting surfacethat is formed at a front end side of the first tapered surfaceand has an outside angle larger than 180&#xb0; with respect to the first tapered surface, a second tapered surfacethat is formed at a front end side of the connecting surfaceand has an outside angle smaller than 180&#xb0; with respect to the connecting surface, and a bent portionin which a front end portion of the second tapered surfaceis bent inwardly so as to hold a writing ballinserted into a ball houseA boundary between the first tapered surfaceand the connecting surfaceis referred to as a first shoulder portion, and a boundary between the second tapered surfaceand the bent portiona second shoulder portion. The second shoulder portionis located inside a virtual tangent linebetween the first shoulder portionand the writing ball

Ball-point pen tip and ink refill

Growing community of inventors

Yokohama, Japan

Atsushi Nakajima