Fujisawa Pharmaceutical Company, Ltd.

Atsushi Kuno

Hisashi Takasugi

Takao Takaya

Hiroyoshi Sakai

Yoshie Sugiyama

Yoshikazu Inoue

Kumi Yamasaki

Mitsuru Ohkubo

Hiroaki Mizuno

Kazuhiro Maeda

Kimio Esumi

Yoshie Sakamoto

Guanidine derivatives

Benzoylguanidine derivatives as medicaments

Guanidine derivatives as inhibitors of Na.sup.+ /H.sup.+  exchange in

Oxadiazole derivatives having acetylcholinesterase-inhibitory and

The invention relates to a compound useful as an anticonvulsant, and for treatment of delayed neuronal death, the compound being a bicyclic amine of the formula: ##STR1## wherein R.sup.1 is lower alkyl,

Bicyclic amine compound and a process for the preparation thereof

The invention relates to cardioprotective compounds of the formula: ##STR1## wherein R.sup.1, R.sup.2 R.sup.3 and R.sup.4 are moieties as described in the specification.

N-containing heterocyclic compounds, compositions and use

The invention relates to a pharmaceutical composition as a therapeutic agent for ischemic disease comprising a compound of the formula ##STR1## wherein R.sup.1 is carbamoyl substituted with morpholino (lower) alkyl, thiomorpholino(lower)alkyl or lower alkylamino(lower)alkyl; or ureido substituted with lower alkylamino(lower)alkyl; and

N-containing heterocyclic compounds, and composition comprising the same

The invention relates to diphenylpyridazine compounds useful in the treatment of cerebrovascular disease, of the formula: ##STR1## wherein R.sup.1 is piperazinyl(lower)alkyl, carbamoyl substituted with piperazinyl(lower)alkyl, or piperazinylcarbonyl, in each of which a piperazinyl group may be substituted with lower alkyl,

Di phenylpyridazine compounds, processes for the preparation thereof and

An N-containing heterocyclic compound of the formula: ##STR1## wherein R.sup.1 is lower alkyl optionally substituted with hydroxy, halogen or a heterocyclic group, carboxy, esterified carboxy, carbamoyl optionally substituted with heterocyclic(lower)alkyl or lower alkylamino(lower)alkyl, N-containing heterocycliccarbonyl optionally substituted with lower alkyl, or ureido optionally substituted with lower alkylamino(lower)alkyl, and

Morpholine containing pyridine compounds, compositions and use

The invention relates to compounds for treatment of hypertension, and cardiovascular and cerebrovascular diseases, which compounds are of the formula: ##STR1## wherein R.sup.1 is piperazinyl(lower)alkyl, carbamoyl substituted with piperazinyl(lower)alkyl, or piperazinylcarbonyl, in each of which a piperazinyl group may be substituted with lower alkyl, and

Diphenylpyridine compounds, processes for the preparation thereof and

The invention relates to new pyrimidine derivatives, useful in the treatment of cerebrovascular disease, of the formula: ##STR1## wherein Ar, R.sup.1, R.sup.2 and R.sup.3 are defined in the specification.

Pyrimidine derivatives and composition of the same

The invention relates to pyrimidine derivatives and their pharmaceutically acceptable salts which are useful in the treatment of cerebrovascular diseases, to processes for preparation thereof and to the composition containing the same, said pyrimidine derivatives being represented by the following formula: ##STR1## wherein Ar, R.sup.1, R.sup.2 and R.sup.3 are as defined in the disclosure.

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Osaka, Japan

Atsushi Kuno