Yamanouchi Pharmaceutical Company Ltd.

Other

Astellas Pharma Gmbh

Atsushi Kajiyama

Masahiro Yanagisawa

Muneo Fukui

Tadayoshi Ohmura

Takao Mizumoto

Satoru Yoneya

Hiroshi Sugiura

Yoshinori Masuda

Hirokazu Takagi

Toshiharu Hosono

Janaki Ram Nyshadham

Masayoshi Aruga

Saburo Higuchi

Yoshiaki Soeishi

Kouji Tomuro

Tamio Hikosaka

Shigeru Masuyama

The present invention relates to a pharmaceutical composition useful for rapid disintegration, which comprises a sparingly soluble medicament held on a gel-forming water-soluble polymer as a solid dispersion, wherein it contains a salt substance that comprises an alkali and a weak or strong acid and has an endothermic standard enthalpy of solution or heat of solution. Since rapid disintegration of the pharmaceutical composition of the present invention and rapid dissolution of the medicament contained in the preparation can be made in the digestive tracts pH-independently, good bioavailability can be attained.

Rapidly disintegrable pharmaceutical composition

Technical field

Tablets quickly disintegrating in the oral cavity and process for producing the same

A coating material for controlling drug release, useful for long acting formulations--e.g. for once-a-day administration, and to a long acting granular composition comprising a drug (especially one conventionally difficult to prepare in long acting form) coated with the coating material. This composition may be mixed with other granular drug formulations. The drug-release controlling coating material comprising, in a specific ratio, one specific water-insoluble and low water-permeability polymers and two materials differing from each other in the pH-dependency of their solubility (pH-dependent polymer-materials).

Drug release controlling coating material for long acting formulations

A coating material for controlling drug release, useful for long acting formulations--e.g. for once-a-day administration, and to a long acting granular composition comprising a drug (especially one conventionally difficult to prepare in long acting form) coated with the coating material. This composition may be mixed with other granular drug formulations. The drug-release controlling coating material comprising, in a specific ration, one specific water-insoluble and low water-permeability polymers and two materials differing from each other in the pH-dependency of their solubility (pH-dependent polymer-materials).

Drug-release controlling coating material for long acting formulations

A pharmaceutical controlled-release individual unit or multiple units formulation in which the individual unit comprises a granulation product obtained by adding a release controlling agent to a mixture of a physiologically active substance and units-forming substance(s) and granulating and resultant mixture, said granulation product (granules) being substantially not disintegrated but gradually releasing the physiologically active substance in the gastrointestinal tract.

Controlled-release multiple units pharmaceutical formulation

Growing community of inventors

Shizuoka, Japan

Atsushi Kajiyama