Eisai Company, Limited

Sumitomo Chemical Company, Limited

Eisai R&d Management Co., Ltd.

National Institute of Advanced Industrial Science and Technology

Toyo Tire Rubber Co., Ltd.

Jx Nippon Mining Metals Corporation

Atsushi Inoue

Jean-Christophe P Harmange

Mark Spyvee

Toshiyuki Araki

Richard S Clark

Takashi Omura

Seiichi Kobayashi

Isao Tanaka

Tadashi Nagakura

Kenzo Muramoto

Satoshi Yamamoto

Naoki Yoneda

Tomohiro Matsushima

Fumiyoshi Matsuura

Kazunobu Kira

Makoto Kotake

Hiroshi Azuma

Yoshiyuki Kawakami

Shinsuke Hirota

Hiroshi Shirota

Hong Du

Kenichi Chiba

Tatsuo Horizoe

Yoshiharu Mizui

Takao Omae

Fabian Gusovsky

Masaki Goto

Kazutomi Kusano

John (Yuan) Wang

Masanori Fujita

Kimiyo Tabata

Yoshikazu Kuboi

Hideki Sakurai

Yoshihito Eguchi

Akifumi Kimura

Takatoshi Kawai

Yong-Chun Shen

Megumi Kawada

Kingo Akahori

Roch Boivin

Yimin Jiang

Takeshi Washimi

Nobutaka Kunimi

Xiang-Yi Li

Jesse Chow

Charles-André Lemelin

Sigeru Sasaki

Yasushi Okamoto

Osamu Asano

Shigeru Sasaki

Nobuhisa Watanabe

Renu Wadhwa

Takao Saeki

Kouji Toishi

Sunil Kaul

Yoshio Yamada

Mitsuaki Hashiyama

Masahiro Sakurai

Ray Wood

Takashi Satoh

Fumiya Nemoto

Maki Shiota

John Wang

The amino acid sequences of paratope regions involved in internalizing function of an anti-mortalin antibody into tumor cells were determined for the L-chain and H-chain variable regions of cellular internalizing anti-mortalin antibodies and non-internalizing anti-mortalin antibodies. Cancer-cell-specific drug delivery is provided by using the mortalin-binding activity of a single-chain antibody (scFv) wherein L-chain and H-chain variable regions both having the paratope region are linked together via a peptide linker. Also, the sequence of 6 amino acids of an epitope to be recognized by an anti-mortalin antibody having the internalizing function was determined. With the use of an expression vector comprising a nucleic acid that encodes the epitope, an agent for accelerating internalization of a mortalin antibody, a drug bound thereto, and the like into cancer cells is provided.

Paratope and epitope of anti-mortalin antibody

The present invention provides methods for the use of compounds having formula (I) in the treatment of various disorders including inflammatory or autoimmune disorders, and disorders involving malignancy or increased angiogenesis, wherein R-R, t, X, Y, Z, and n are as defined herein.

Macrocyclic compounds useful as pharmaceuticals

A compound represented by the following general formula (1) or salts thereof or hydrates of the foregoing: wherein R, R, Rand Reach independently represent hydrogen, etc.; Rrepresents optionally substituted phenyl, etc.; Rrepresents optionally substituted C6-10 aryl, etc.; and Zand Zeach independently represent hydrogen.

Triazolone derivatives

A Compound represented by the following general formula (1): wherein R, R, Rand Reach independently represent hydrogen, etc.; Rrepresents optionally substituted phenyl, etc.; Rrepresents optionally substituted C6-10 aryl, etc.; and Zand Zeach independently represent hydrogen or salts thereof or hydrates of the foregoing.

The present invention provides compositions comprising compounds having formula (I): 

The present invention pertains to a sputtering target transport box having a void the size of a sputtering target, wherein supports for mechanical transport are provided to the bottom plate of the transport box, and a wheel for man-powered transport is provided to the edge portion of the bottom plate. Provided thereby is a sputtering target transport box in which the removal and transport of a sputtering target is easy, and which enables the transport of a sputtering target without causing any damage thereto.

Sputtering target transport box

A Compound represented by the following general formula (1), salts thereof or hydrates of the foregoing is a novel compound useful for treatment and/or prevention of diseases associated with thrombus formation, and which is safer with suitable physicochemical stability. [wherein R, R, Rand Reach independently represent hydrogen, etc.; Rrepresents optionally substituted phenyl, etc.; Rrepresents optionally substituted C6-10 aryl, etc.; and Zand Zeach independently represent hydrogen]

The present invention provides compounds having formula (I): 

Amidino derivatives represented by the following general formula (I):{where X is a group represented by RSONR&#x2014; (wherein Rrepresents optionally substituted Caryl, etc. and Rrepresents hydrogen atom, etc.), etc., Arrepresents 2,6-naphthylene, etc., Rrepresents hydrogen atom, etc. and Y represents carboxyphenyl, etc.}and their pharmacologically acceptable salts or solvates.

Amidino derivatives and anticoagulants and thrombosis therapeutic agents containing them

There is provided a monoazo compound which is useful as a reactive dye for dyeing or printing a fiber material in an orange to scarlet color; and intermediate compounds for producing the compound is provided; the monoazo compound being represented by the following formula (1): ##STR1## wherein m represents 0 or 1; R.sup.1 represents a hydrogen atom or a lower alkyl group; D represents a specific diazo component of benzene type having substitution of a fiber reactive group; B.sup.1 represents a direct bond or connecting group; Z.sup.1 represents an alkylcarbonyl group, phenylcarbonyl group or a fiber-reactive group of vinylsulfone, triazine or pirimidine type; a group represented by --NR.sup.1 -- bonds to 6-position or 7-position of a naphthalene ring; and the intermediate compounds being represented by the following formulae (A) or (B): ##STR2## wherein U represents a connecting group such as alkylene and the like, Y represents vinyl or --CH.sub.2 CH.sub.2 L, and L represents a group eliminatable by an action of alkali.

Monoazo compound and an intermediate for a fiber-reactive dye compound

A monoazo compound useful for dyeing or printing a fiber material represented by the following general formula (I): ##STR1## wherein R.sup.1 represents a hydrogen atom or alkyl; U.sup.1 and U.sup.2 represent a group of the following general formula (U1), (U2) or (U3): ##STR2## wherein Y.sup.1, Y.sup.2 and Y.sup.3 represent --CH.dbd.CH.sub.2 or --CH.sub.2 CH.sub.2 Z wherein Z represents a group which can be eliminated by the action of an alkali; and X.sup.1 and X.sup.2 represent halogeno, pyridinio or a group of the following general formula (X1), (X2), (X3) or (X4): ##STR3## or a salt thereof.

Monoazo compounds and process for dyeing or printing fiber materials

A bisazo compound of the following formula: ##STR1## wherein R.sup.1 and R.sup.3 are each hydrogen or alkyl; D is phenylene or naphthylene; one of X.sup.1 and X.sup.2 is NH.sub.2 and the other is OH; Z.sup.1 and Z.sup.2 are each --CH.dbd.CH.sub.2 or --CH.dbd.CH.sub.2 Z' in which Z' is a splittable group; B is monosulfophenylene, monosulfophenylene-methylene or mono- or di-sulfonaphthylene-methylene; U is phenylene or an aliphatic bridging group; and J is an amono-derivative group or, J may be alkoxy when X.sup.1 is OH and U is phenylene, and J may be alkoxy or phenoxy when X.sup.1 is OH and U is the aliphatic bridging group. This compound is useful for dyeing or printing fiber materials and gives a dyed or printed product having a color superior in various fastness properties with superior build-up property.

Bisazo compounds and use thereof as fiber reactive dyes

In a cleaning device for an electrophotographic copying machine having a cleaning member unified in structure by bonding a blade member and a holding member together by an adhesive, the improvement characterized in that a heat-sensitive adhesive having a contact angle with water at 23.degree. C. of 90.degree. to 100.degree. is used as the adhesive.

Cleaning device for electrophotographic copying machines

Growing community of inventors

Ibaraki, Japan

Atsushi Inoue