Sumitomo Chemical Company, Limited

Atsushi Furutani

Shinzo Seko

Gohfu Suzukamo

Toshiya Takahashi

Michio Yamamoto

Hideki Ushio

Takuo Hibi

Hirokazu Murata

Etsuko Fukuda

Masami Fukao

Naoto Konya

Kazuhiro Tada

Hiroaki Hibino

Kazuyuki Tanaka

Process for the preparation of vitamin a, intermediates, and process for the preparation of the intermediates

A tetraene derivative of the formula (1): ##STR1## wherein Ar represents an aryl group which may be optionally substituted with at least one substituent, and R.sup.1 and R.sup.2 are identical or different and represent a hydrogen atom, a lower alkyl group or a protective group of a hydroxyl group; synthesis methods therefor and synthesis methods using the same.

Tetraene derivative and process for producing the same

A process for producing 1-bromo-4-phenylbutane of the formula (1): ##STR1## which is characterized by the steps of; reacting 4-bromobutyryl halide of the formula (2): ##STR2## where X is a halogen atom, with benzene in the presence of a Lewis acid to give a 4-bromobutyrophenone of the formula (3): ##STR3## and reacting 4-bromobutyrophenone compound of the formula (3) with hydrogen in the presence of a metal catalyst.

Process for producing 1-bromo-4-phenylbutane

The present invention concerns a process for producing crystals of 3-amino-2-hydroxyacetophenone salt having a high bulk density and improved flow properties, by treating 3-amino-2-hydroxyacetophenone of formula (1) ##STR1## or hydrogen halide salt thereof with sulfuric acid, in a solvent.

Process for producing improved crystals of 3-amino-2-hydroxyacetophenone

3-�4-(4-Phenyl-1-butoxy)benzoyl!amino-2-hydroxyacetophenone is prepared by reacting a benzoate ester with a halobutylbenzene in the presence of a basic compound and an aprotic polar compound in an aromatic hydrocarbon solvent to obtain a corresponding ether, alkali hydrolyzing the ether in an aromatic hydrocarbon solvent and precipitating a hydrolysate with an acid to obtain 4-(4-phenyl-1-butoxy)benzoic acid, reacting a halogenating agent with this benzoic acid derivative in an aromatic hydrocarbon solvent to obtain an acid halide, and reacting the acid halide in an aromatic hydrocarbon solvent with a corresponding aromatic amine.

Process for preparing aromatic amide compound

A process is disclosed for producing an amine by carrying out a reductive amination of a cyclic ketone or by carrying out a reduction of an imino derivative of a cyclic ketone to the corresponding amine which process is characterized in using a cobalt catalyst containing a carbonate of an alkaline earth metal and/or lanthanum oxide.

Process for producing amines

Amines are produced in high yield by the process which comprises allowing a cyclic ketone to react with ammonia in the presence of active carbon to produce imino derivatives and then, allowing the imino derivatives to react with hydrogen in the presence of a hydrogenating catalyst.

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Takatsuki, Japan

Atsushi Furutani