Daiichi Sankyo Company, Limited

Atsunobu Sakamoto

Kazuhiro Yoshida

Yuji Kasuya

Tatsuya Inoue

Satoshi Komoriya

Kayoko Masuda

Takashi Ohnuki

Yoko Murakami

Masako Minami

Takeshi Fukuda

Yasunori Ono

Yasuhiro Nakagami

Mayumi Iizuka

Emiko Hatano

Masaru Iwasaki

Naoki Tanaka

The present invention relates to a terpenoid derivative that has the ability to activate the Keap1/Nrf2/ARE signaling pathway and is excellent in anti-inflammatory action and cytoprotective action, and a sustained-release pharmaceutical composition effective for the treatment and prevention of a posterior eye disease caused by oxidative stress, comprising the terpenoid derivative as an active ingredient. The present invention provides a local administration-type sustained-release pharmaceutical composition for the treatment or prevention of a posterior eye disease, comprising the terpenoid derivative of the present invention as an active ingredient, wherein the sustained-release pharmaceutical composition maintains a pharmacological action thereof for 1 week or longer by the sustained release of the terpenoid derivative under physiological conditions and has a base material administrable to the vitreous body and a form administrable to the vitreous body.

Sustained-release pharmaceutical composition for treatment and prevention of eye disease

The present invention provides a compound which enhances the production of erythropoietin. The present invention provides, for example, a compound represented by the formula (1) wherein R: -Q, -Q-X-Q, or -Q-X-Q-Y-Q: a monocyclic or bicyclic aromatic heterocyclic group; Q, Q: an aromatic hydrocarbon ring group or a monocyclic aromatic heterocyclic group; X: &#x2014;CONH&#x2014;, &#x2014;CONHCH&#x2014;, &#x2014;CHOCH&#x2014;, &#x2014;NHCHCH&#x2014;, or the like; Y: a single bond, &#x2014;O&#x2014;, &#x2014;(CH)&#x2014;, or &#x2014;O&#x2014;(CH)&#x2014;; m, n: an integer from 1 to 3; R: H or an alkyl group; and R: H, an alkoxycarbonyl group, a carboxy group, an aromatic hydrocarbon ring group, or a monocyclic aromatic heterocyclic group.

4-alkanoylamino-3-pyrazolone derivative

Growing community of inventors

Edogawa-ku, Japan

Atsunobu Sakamoto