Novartis Ag

Atsuko Nihonyanagi

Werner Breitenstein

Keiichi Masuya

Claus Ehrhardt

Yuki Iwaki

Nils Ostermann

Takeru Ehara

Philipp Grosche

Fumiaki Yokokawa

Juergen Klaus Maibaum

Takanori Kanazawa

Masaki Suzuki

Kazuhide Konishi

Yuko Hitomi

Atsushi Toyao

3,4-substituted piperidine compounds, these compounds for use in the diagnostic and therapeutic treatment of a warm-blooded animal, especially for the treatment of a disease (=disorder) that depends on activity of renin; the use of a compound of that class for the preparation of a pharmaceutical formulation for the treatment of a disease that depends on activity of renin; the use of a compound of that class in the treatment of a disease that depends on activity of renin; pharmaceutical formulations comprising a 3,4-substituted piperidine compound, and/or a method of treatment comprising administering a 3,4-substituted piperidine compound, a method for the manufacture of a 3,4-substituted piperidine compound, and novel intermediates and partial steps for their synthesis are disclosed. The 3,4-disubstituted piperidine compounds have the formula I, 

Organic compounds

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Ibaraki, Japan

Atsuko Nihonyanagi