Technion Research & Development Foundation Ltd

Atif Mahammed

Zeev Gross

Michael Aviram

Adi Haber

Bianca Fuhrman

Silvia Mandel

Raymond Coleman

Irena Saltsman

Tamar Amit

Orit Bar-Am

Moussa BH Youdim

Transition metal complexes of amphiphilic/bipolar corroles, optically active isomers or pharmaceutically acceptable salts thereof are useful for prevention of a cardiovascular disease or disorder in a subject susceptible to develop such a cardiovascular disease or disorder.

Transition metal complexes of corroles for preventing cardiovascular diseases or disorders

Corroles of formula I, wherein Ar is aryl or heteroaryl; M is absent or is a metal selected from Al, Ga, Co, Mn, Fe, Ru, Sn, Cr or Rh; E, Eand E, the same or different, each is H, SOCl, SOH, SONRR, COH, COR, COC, CONRR, CHO or NO, R is alkyl or aryl, and Rand R, the same or different, each is H, alkyl, aryl or together with the N atom to which they are attached form a saturated 5-6 membered ring optionally containing a further heteroatom selected from O, S and N; and Eis H or CHO; or Eand Eare H and Eand Eare each SO, both SOgroups being linked by a bridge RN(R)-phenyl-(R)NR, wherein Ris H, alkyl, phenyl or aralkyl, and Ris alkylene; and provided that at least one of E, E, Eand Eis not H, are provided. The corroles can be used for tumor detection and treatment, in photovoltaic devices, as catalysts and as intermediates.

Method for the preparation of selectively-substituted corroles and new substituted corroles

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Muawya Village, Israel

Atif Mahammed